SGCB
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Official Full Name
sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) -
Overview
This gene encodes a member of the sarcoglycan family. Sarcoglycans are transmembrane components in the dystrophin-glycoprotein complex which help stabilize the muscle fiber membranes and link the muscle cytoskeleton to the extracellular matrix. Mutations in this gene have been associated with limb-girdle muscular dystrophy. -
Synonyms
SGCB;sarcoglycan, beta (43kDa dystrophin-associated glycoprotein);LGMD2E, sarcoglycan, beta (43kD dystrophin associated glycoprotein);beta-sarcoglycan;A3b;SGC;43DAG;beta-SG;43 kDa dystrophin-associated glycoprotein;limb girdle muscular dystrophy
Recombinant Proteins
- Mouse
- Chicken
- Zebrafish
- Human
- Mus musculus
- Bovine
- Mammalian Cell
- E.coli
- HEK293
- E.coli expression system
- Mammalian cells
- HEK293T
- E. coli
- His
- Non
- Flag
- His&Fc&Avi
- Myc&DDK
- N-His&T7
Involved Pathway
SGCB involved in several pathways and played different roles in them. We selected most pathways SGCB participated on our site, such as Hypertrophic cardiomyopathy (HCM),Arrhythmogenic right ventricular cardiomyopathy (ARVC),Dilated cardiomyopathy, which may be useful for your reference. Also, other proteins which involved in the same pathway with SGCB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hypertrophic cardiomyopathy (HCM) | TPM1,MYL2,LAMA2,CACNG1,ITGA9,ITGA10,TNNC1,ITGA4,ITGA5,DMD |
| Viral myocarditis | HLA-DRA,CYCS,CAV1,HLA-DPB1,CD28,HLA-DRB1,HLA-G,H2-AA,ITGB2L,SGCD |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | ITGA7,DAG1,CACNA2D3,CACNG6,SGCD,DMD,CACNB4,CTNNA1,ACTN3,CACNG7 |
| Dilated cardiomyopathy | ITGB3,CACNA2D2,ITGB4,TPM3,TGFB1,TNF,Adcy4,ITGA6,CACNA2D4,ACTG1 |
Protein Function
SGCB has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by SGCB itself. We selected most functions SGCB had, and list some proteins which have the same functions with SGCB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
SGCB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SGCB here. Most of them are supplied by our site. Hope this information will be useful for your research of SGCB.
TRIM63
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References
- Stehlikova, K; Skalova, D; et al. Autosomal recessive limb-girdle muscular dystrophies in the Czech Republic. BMC NEUROLOGY 14:-(2014).
- Gibertini, S; Zanotti, S; et al. Fibrosis and inflammation are greater in muscles of beta-sarcoglycan-null mouse than mdx mouse. CELL AND TISSUE RESEARCH 356:427-443(2014).
