SETX
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Official Full Name
senataxin -
Overview
This gene encodes a protein named for its homology to the Sen1p protein of fungi which has RNA helicase activity encoded by a domain at the C-terminal end of the protein. The protein encoded by this gene contains a DNA/RNA helicase domain at its C-terminal end which suggests that it may be involved in both DNA and RNA processing. Mutations in this gene have been associated with ataxia-ocular apraxia-2 (AOA2) and an autosomal dominant form of juvenile amyotrophic lateral sclerosis (ALS4). -
Synonyms
SETX;senataxin;ALS4, amyotrophic lateral sclerosis 4 , SCAR1, spinocerebellar ataxia, recessive, non Friedreich type 1;probable helicase senataxin;AOA2;KIAA0625;ALS4;Amyotrophic lateral sclerosis 4 protein;bA479K20.2;DKFZp781B151;FLJ12840;FLJ43459;SCAR1;SEN1 homolog;SETX_HUMAN;OTTHUMP00000022428
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SETX-14989M | Recombinant Mouse SETX Protein | Mammalian Cell | Mouse | His |
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| SETX-1119H | Recombinant Human SETX Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| SETX-8074M | Recombinant Mouse SETX Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| SETX-8074M-B | Recombinant Mouse SETX Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
SETX involved in several pathways and played different roles in them. We selected most pathways SETX participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SETX were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
SETX has several biochemical functions, for example, ATP binding,helicase activity,hydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SETX itself. We selected most functions SETX had, and list some proteins which have the same functions with SETX. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | NME2B.1,SMC1A,UBE2NA,DDX39B,CKB,MKI67,GTF2F2A,IKBKAP,YME1L1,DDX49 |
| helicase activity | DNA2,SMARCA2,DDX19B,DHX57,FANCM,SUPV3L1,ERCC6L,SNRNP200,CHD9,ANXA1 |
| nucleotide binding | DAZL,TNRC6B,ACTB1,IGF1RB,ABCG5,MAPKAPK2A,RAD51L1,MAPK12B,PANK1A,ABCD3B |
| transcription termination site sequence-specific DNA binding | XRN2 |
| identical protein binding | GLUD1,ADIPOR2,ATXN3,SAFB2,NELL2,PIK3AP1,KCTD13,SDCBP,KCTD17,HCN2 |
| hydrolase activity | ATP2B1,PRSS30,EHD2,DPEP3,FBP1B,MBLAC2,PTPRK,CAPN2B,MCPT1,ABHD13 |
| protein binding | TET2,ACTL8,SLC7A11,CPNE7,MAT2B,CRBN,PDLIM7,ARL4D,PACS1,PAM |
Interacting Protein
SETX has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SETX here. Most of them are supplied by our site. Hope this information will be useful for your research of SETX.
Ezh2;Jarid2;Eed
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