SERPINC1
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Official Full Name
serpin peptidase inhibitor, clade C (antithrombin), member 1 -
Overview
The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. -
Synonyms
SERPINC1;serpin peptidase inhibitor, clade C (antithrombin), member 1;AT3;ATIII;MGC22579;antithrombin (aa 375-432);antithrombin III;coding sequence signal peptide antithrombin part 1;signal peptide antithrombin part 1;serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1;Antithrombin-III;Serpin C1;PRO0309;OTTHUMP00000035393;serine-cysteine proteinase inhibitor clade C member 1
Recombinant Proteins
- Human
- Cynomolgus
- Mouse
- Rhesus macaque
- Zebrafish
- Pig
- Bovine
- Rat
- Rabbit
- E.coli
- HEK293
- Insect Cell
- Plasma
- Mammalian Cell
- Human Cell
- Porcine plasma
- Rat Plasma
- Mouse Plasma
- Rabbit Plasma
- HEK293T
- Human Plasma
- GST
- His
- Non
- Myc&DDK
- His&GST&Myc
- His&Fc&Avi
- Fc
Involved Pathway
SERPINC1 involved in several pathways and played different roles in them. We selected most pathways SERPINC1 participated on our site, such as Complement and coagulation cascades, which may be useful for your reference. Also, other proteins which involved in the same pathway with SERPINC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Complement and coagulation cascades | KNG1,TFPI,F8,F9,SERPINF2,C1QC,CPB2,KLKB1,Serpina1c,C8B |
Protein Function
SERPINC1 has several biochemical functions, for example, heparin binding,protease binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SERPINC1 itself. We selected most functions SERPINC1 had, and list some proteins which have the same functions with SERPINC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protease binding | PEO1,MBP,TNF,F3,TRIP4,CST3,SRI,KIT,ADRM1,ECM1 |
| heparin binding | GREM2,LPL,ANG,CLEC3B,SERPIND1,CRISPLD2,FMOD,ADAMTSL5,FGFRL1,FGF10 |
| serine-type endopeptidase inhibitor activity | SERPINB6,APPB,AMBP,SERPINF1,COL7A1,WFDC10A,SPOCK1,SERPINB1B,SERPINA5,SERPINB1L4 |
| protein binding | PRKAR2A,RXRG,YOD1,RFFL,RNF40,EXO1,HBZ,WIBG,CD28,PLK1 |
Interacting Protein
SERPINC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SERPINC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SERPINC1.
C1QBP;F2;PLCG1
Resources
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References
- Zeng, W; Tang, L; et al. Genetic analysis should be included in clinical practice when screening for antithrombin deficiency. THROMBOSIS AND HAEMOSTASIS 113:262-271(2015).
- Luxembourg, B; D'Souza, M; et al. Prediction of the pathogenicity of antithrombin sequence variations by in silico methods. THROMBOSIS RESEARCH 135:404-409(2015).
