SERPINA5
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Official Full Name
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 -
Overview
The protein encoded by this gene is a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. This gene is one in a cluster of serpin genes located on the q arm of chromosome 14. This family member is a glycoprotein that can inhibit several serine proteases, including protein C and various plasminogen activators and kallikreins, and it thus plays diverse roles in hemostasis and thrombosis in multiple organs. [provided by RefSeq, Aug 2012] -
Synonyms
SERPINA5;serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5;PCI;PAI3;PAI-3;PCI-B;PROCI;PLANH3;plasma serine protease inhibitor;protein C inhibitor;plasminogen activator inhibitor-3;acrosomal serine protease inhibitor;plasminogen activator inhibitor III;serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
Recombinant Proteins
- Mouse
- Rhesus macaque
- Human
- Mammalian Cell
- E.coli
- Human Cell
- HEK293
- Insect Cell
- Mammalian cells
- His
- Non
- His&Fc&Avi
Involved Pathway
SERPINA5 involved in several pathways and played different roles in them. We selected most pathways SERPINA5 participated on our site, such as Complement and coagulation cascades, which may be useful for your reference. Also, other proteins which involved in the same pathway with SERPINA5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Complement and coagulation cascades | KNG1,MASP2,SERPING1,F8,C1S,C4BP,F12,F5,C6,LOC100514666 |
Protein Function
SERPINA5 has several biochemical functions, for example, acrosin binding,glycosaminoglycan binding,heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SERPINA5 itself. We selected most functions SERPINA5 had, and list some proteins which have the same functions with SERPINA5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| acrosin binding | ZP2,ZP3 |
| serine-type endopeptidase inhibitor activity | SERPINA12,SERPINA1,SPOCK1,A1i3,SERPINB10,SPINK3,SERPINB13,SERPINB12,SERPINH1B,SERPINB2 |
| phosphatidylcholine binding | APOC1,APOA1,CHMP3,CETP,VPS24,APOA4A,CHMP2A,ESYT2,APOA2,RPE65 |
| protease binding | TNF,COMP,CCDC71L,ITGB1,ITGAV,CHL1,TYSND1,PYCARD,DVL3,SELL |
| heparin binding | VEGFAB,CHRD,LPA,FGF2,BMP7,CCL23,WISP2,ABP1,RSPO2,NRP1A |
| retinoic acid binding | UGT1A7,CRABP2A,UGT1A3,CRABP1,CRABP2,PTGDSB,LCN12,CYP26A1,UGT1A9,CRABP2B |
| glycosaminoglycan binding | BGN,TGFBR3,ENG,SPOCK2,SPOCK3,EGFLAM,Shh,DCN,EPYC,VCAN |
| protein binding | APAF1,IL11,KATNBL1,RFX6,PABPC1,VPS53,TCOF1,PRAM1,TAS2R16,ACVR1 |
Interacting Protein
SERPINA5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SERPINA5 here. Most of them are supplied by our site. Hope this information will be useful for your research of SERPINA5.
CBL;HRSP12;EP300;EPS8;COPS6;sbcD;PIAS4;RCHY1
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