SEMA5A
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Official Full Name
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -
Overview
This gene belongs to the semaphorin gene family that encodes membrane proteins containing a semaphorin domain and several thrombospondin type-1 repeats. Members of this family are involved in axonal guidance during neural development. This gene has been implicated as an autism susceptibility gene.[provided by RefSeq, Jan 2010] -
Synonyms
SEMA5A;sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A;semF;SEMAF;semaphorin-5A;sema F;semaphorin F;semaphorin-F;semaphorin 5A
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- Zebrafish
- HEK293
- Mammalian cells
- CHO
- Mammalian Cell
- Human Cell
- E.coli
- HEK293T
- His
- Fc
- Non
- Flag
- His&Fc&Avi
- Myc&DDK
Involved Pathway
SEMA5A involved in several pathways and played different roles in them. We selected most pathways SEMA5A participated on our site, such as Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with SEMA5A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Axon guidance | NRG3,RHOAE,UNC5A,PEA15,DPYSL3,CFL2,SEMA3D,EPHA10,SEMA6C,ARPC1B |
Protein Function
SEMA5A has several biochemical functions, for example, axon guidance receptor activity,chemorepellent activity,chondroitin sulfate proteoglycan binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SEMA5A itself. We selected most functions SEMA5A had, and list some proteins which have the same functions with SEMA5A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chemorepellent activity | SEMA3AA,SLIT2,SEMA3AB,SEMA3B,EFNA5,FLRT2,SEMA3FA,FLRT3,SEMA6D,NRG1 |
| heparan sulfate proteoglycan binding | GPC1,CFH,GPC5,GPC6A,GPC1A,AGRN,Itgam&Itgb2,SLIT2,COMP,PLA2G2D |
| semaphorin receptor binding | SEMA3E,SEMA6B,SEMA6E,SEMA4C,SEMA3GA,SEMA4D,SEMA6D,SEMA3D,SEMA5B,SEMA3H |
| axon guidance receptor activity | GFRA3,EPHB3,EPHB1,ROBO2,ROBO1,EPHA7 |
| chondroitin sulfate proteoglycan binding | PTPRF,COL20A1,PTN |
| syndecan binding | SDCBP,HPSE,CHRD,TNC |
Interacting Protein
SEMA5A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SEMA5A here. Most of them are supplied by our site. Hope this information will be useful for your research of SEMA5A.
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References
- Goldberg, JL; Vargas, ME; et al. An oligodendrocyte lineage-specific semaphorin, sema5A, inhibits axon growth by retinal ganglion cells. JOURNAL OF NEUROSCIENCE 24:4989-4999(2004).
- Oster, SF; Bodeker, MO; et al. Invariant Sema5A inhibition serves an ensheathing function during optic nerve development. DEVELOPMENT 130:775-784(2003).
