SEC13
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Official Full Name
SEC13 homolog (S. cerevisiae) -
Overview
The protein encoded by this gene belongs to the SEC13 family of WD-repeat proteins. It is a constituent of the endoplasmic reticulum and the nuclear pore complex. It has similarity to the yeast SEC13 protein, which is required for vesicle biogenesis from endoplasmic reticulum during the transport of proteins. Multiple alternatively spliced transcript variants have been found. -
Synonyms
SEC13;SEC13 homolog (S. cerevisiae);D3S1231E, SEC13 (S. cerevisiae) like 1 , SEC13 like 1 (S. cerevisiae) , SEC13L1;protein SEC13 homolog;npp 20;SEC13R;D3S1231E;Npp20;SEC13 (S. cerevisiae) like 1;SEC13 homolog;SEC13 like 1 (S. cerevisiae);SEC13 like 1 isoform;SEC13 like protein 1;SEC13 protein;SEC13 related protein;SEC13-like protein 1;SEC13-related protein;SEC13_HUMAN;SEC13L1;SEC13-like 1 isoform;npp-20
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rhesus macaque
- Chicken
- Rat
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
SEC13 involved in several pathways and played different roles in them. We selected most pathways SEC13 participated on our site, such as RNA transport,Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with SEC13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RNA transport | THOC2,WIBG,THOC7,PABPC1L2A,EIF3S10,EIF4E2,NUP188,EEF1A1L1,UPF1,PABPC1L |
| Protein processing in endoplasmic reticulum | UBE2J2,NFE2L2A,UBE2D2,PARK2,VIMP,XBP1,NGLY1,BAG2,UBQLN2,STT3B |
Protein Function
SEC13 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SEC13 itself. We selected most functions SEC13 had, and list some proteins which have the same functions with SEC13. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | RABIF,ATP6V0A1,CARKD,ZNF217,CCDC106,PRKD2,LRRFIP1,CHN1,SMR3B,FRMPD1 |
Interacting Protein
SEC13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SEC13 here. Most of them are supplied by our site. Hope this information will be useful for your research of SEC13.
NUP145;TRAF5;Nup98;Nup107;SEC16B
Resources
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References
- Sihn, CR; Suh, EJ; et al. Sec13 induces genomic instability in U2OS cells. EXPERIMENTAL AND MOLECULAR MEDICINE 37:255-260(2005).
- Siddiqi, S; Mansbach, CM; et al. Phosphorylation of Sar1b Protein Releases Liver Fatty Acid-binding Protein from Multiprotein Complex in Intestinal Cytosol Enabling It to Bind to Endoplasmic Reticulum (ER) and Bud the Pre-chylomicron Transport Vesicle. JOURNAL OF BIOLOGICAL CHEMISTRY 287:10178-10188(2012).
