SCP2
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Official Full Name
sterol carrier protein 2 -
Overview
This gene encodes two proteins: sterol carrier protein X (SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 protein, with the 2 proteins sharing a common C-terminus. Evidence suggests that the SCPx protein is a peroxisome-associated thiolase that is involved in the oxidation of branched chain fatty acids, while the SCP2 protein is thought to be an intracellular lipid transfer protein. This gene is highly expressed in organs involved in lipid metabolism, and may play a role in Zellweger syndrome, in which cells are deficient in peroxisomes and have impaired bile acid synthesis. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms. -
Synonyms
SCP2;sterol carrier protein 2;non-specific lipid-transfer protein;sterol carrier protein X;propanoyl-CoA C-acyltransferase;NLTP;SCPX;SCP-2;SCP-X;NSL-TP;SCP-CHI;DKFZp686C12188;DKFZp686D11188
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- E. coli
- In Vitro Cell Free System
- GST
- His
- Non
- His&T7
- Myc&DDK
- His&GST
- His&Fc&Avi
Involved Pathway
SCP2 involved in several pathways and played different roles in them. We selected most pathways SCP2 participated on our site, such as Primary bile acid biosynthesis,Metabolic pathways,PPAR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SCP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| PPAR signaling pathway | PPARD,FABP7B,CYP4A12A,PLIN1,RXRGA,GK,FABP1A,ANGPTL4,PPARA,ACSL5 |
| Metabolic pathways | GLCE,HSD17B8,SLC27A5,PLCZ1,NADKB,PNAT3,B4GALT3,ACSM1,HMGCS1,NAT |
| Primary bile acid biosynthesis | HSD17B4,BRSK2,ACOX2,CYP46A1.1,SLC27A5,AKR1C4,CH25HL1.2,HSD3B7,CYP46A1.4,CYP8B1 |
| Peroxisome | XDH,PRDX1,AGXTA,PIPOX,ACSL3A,ACAA1A,PEX16,NOS2A,ACAA1,ACSL3 |
Protein Function
SCP2 has several biochemical functions, for example, cholesterol binding,fatty-acyl-CoA binding,long-chain fatty acyl-CoA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SCP2 itself. We selected most functions SCP2 had, and list some proteins which have the same functions with SCP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| oleic acid binding | FABP3 |
| fatty-acyl-CoA binding | ACADL,ACADVL,GCDHB,ACADSB,ACOX2,ACADS,ACBD3,HMGCL,SOAT1,ACOT7 |
| sterol transporter activity | NPC1,SCP2A,OSBP,C20orf79 |
| long-chain fatty acyl-CoA binding | ACOT7,DBI |
| receptor binding | RSPO1,EFNA1,SERPINE1,GFRA3,DHRS4,FLT3LG,CXCL12,GSDMA2,FYNB,PIPOX |
| cholesterol binding | APOE,APOEA,APOF,OSBPL7,OSBP2,STARD6,OSBPL10,OSBPL5,PTCH1,PMP2 |
| protein binding | EIF2B5,NCAPH2,HYPM,SCFD1,RAC1,SMCP,PPP1CC,RRP7A,ING5,ZNF212 |
| phosphatidylinositol transporter activity | PITPNBL,PITPNM1,PITPNM3,TNFAIP8L3,PITPNA,PITPNC1 |
Interacting Protein
SCP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SCP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SCP2.
TRIP13;CAV1;Cav1;EPB41;CACNA1A;CREB3;yscL;SF1;sseA;q99ib8-pro_0000045599;pi3p;1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate
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References
- Kneissel, S; Franke, WW; et al. A novel karyoskeletal protein: Characterization of protein NO145, the major component of nucleolar cortical skeleton in Xenopus oocytes. MOLECULAR BIOLOGY OF THE CELL 12:3904-3918(2001).
- Kimura, H; Fujii, H; et al. Lipid-binding proteins in rat and human kidney. KIDNEY INTERNATIONAL 56:S159-S162(1999).
