SCNN1B
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Official Full Name
sodium channel, non-voltage-gated 1, beta subunit -
Overview
Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the beta subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), and Liddle syndrome. [provided by RefSeq, Apr 2009] -
Synonyms
SCNN1B;sodium channel, non-voltage-gated 1, beta subunit;BESC1;ENaCb;SCNEB;ENaCbeta;amiloride-sensitive sodium channel subunit beta;beta-ENaC;beta-NaCH;epithelial Na(+) channel subunit beta;epithelial sodium channel beta-2 subunit;epithelial sodium channel beta-3 subunit;sodium channel, nonvoltage-gated 1, beta;nasal epithelial sodium channel beta subunit;nonvoltage-gated sodium channel 1 subunit beta;amiloride-sensitive sodium channel subunit beta 1
Recombinant Proteins
- Human
- Rabbit
- Rat
- Sheep
- E.coli
- E.Coli or Yeast
- Mammalian Cell
- HEK293
- E.coli expression system
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SCNN1B-3892H | Recombinant Human SCNN1B, His-tagged | E.coli | Human | His | 68-401aa | |
| SCNN1B-3414R | Recombinant Rabbit SCNN1B, His-tagged | E.Coli or Yeast | Rabbit | His | 641 |
|
| Scnn1b-3415R | Recombinant Rat Scnn1b, His-tagged | E.Coli or Yeast | Rat | His | 638 |
|
| SCNN1B-5272R | Recombinant Rat SCNN1B Protein | Mammalian Cell | Rat | His |
|
|
| SCNN1B-2028HCL | Recombinant Human SCNN1B 293 Cell Lysate | HEK293 | Human | Non |
|
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| RFL22222OF | Recombinant Full Length Sheep Amiloride-Sensitive Sodium Channel Subunit Beta(Scnn1B) Protein, His-Tagged | E.coli expression system | Sheep | His | Full L. Full Length (1-632) |
|
| SCNN1B-4931R | Recombinant Rat SCNN1B Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
|
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| SCNN1B-4931R-B | Recombinant Rat SCNN1B Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
|
Involved Pathway
SCNN1B involved in several pathways and played different roles in them. We selected most pathways SCNN1B participated on our site, such as Taste transduction,Aldosterone-regulated sodium reabsorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with SCNN1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Taste transduction | TAS2R120,PRKACB,TAS2R139,TAS2R144,TAS2R38,TAS2R103,TAS2R138,TAS2R13,GNG3,GRM4 |
| Aldosterone-regulated sodium reabsorption | SCNN1G,INSR,PIK3R3,ATP1A1,NEDD4L,KRAS,MAPK3,PIK3R5,SLC9A3R2,INS2 |
Protein Function
SCNN1B has several biochemical functions, for example, WW domain binding,contributes_to ligand-gated sodium channel activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SCNN1B itself. We selected most functions SCNN1B had, and list some proteins which have the same functions with SCNN1B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to ligand-gated sodium channel activity | SCNN1A,SCNN1G |
| protein binding | RHOT1,PRKG1,PALB2,TXLNB,PCP4,CSRNP1,ITM2C,MICU1,FKBP1B,DOCK4 |
| WW domain binding | PPARG,TCEAL1,TCEAL3,WBP11,CDC25C,FAM189B,TCEAL6,NFE2,LITAF,PMEPA1 |
Interacting Protein
SCNN1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SCNN1B here. Most of them are supplied by our site. Hope this information will be useful for your research of SCNN1B.
NEDD4;NEDD4L;COMMD1
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References
- Mutesa, L; Azad, AK; et al. Genetic Analysis of Rwandan Patients With Cystic Fibrosis-Like Symptoms Identification of Novel Cystic Fibrosis Transmembrane Conductance Regulator and Epithelial Sodium Channel Gene Variants. CHEST 135:1233-1242(2009).
- Giraldez, T; Afonso-Oramas, D; et al. Cloning and functional expression of a new epithelial sodium channel delta subunit isoform differentially expressed in neurons of the human and monkey telencephalon. JOURNAL OF NEUROCHEMISTRY 102:1304-1315(2007).
