SCN5A
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Official Full Name
sodium channel, voltage-gated, type V, alpha subunit -
Overview
The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] -
Synonyms
SCN5A;sodium channel, voltage-gated, type V, alpha subunit;HB1;HB2;HH1;IVF;VF1;HBBD;ICCD;LQT3;SSS1;CDCD2;CMD1E;CMPD2;PFHB1;Nav1.5;sodium channel protein type 5 subunit alpha;voltage-gated sodium channel subunit alpha Nav1.5;sodium channel protein cardiac muscle subunit alpha;cardiac tetrodotoxin-insensitive voltage-dependent sodium channel alpha subunit
Recombinant Proteins
- Human
- Rat
- E.coli
- Mammalian Cell
- E. coli
- Wheat Germ
- HEK293
- His
- GST
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SCN5A-2537H | Recombinant Human SCN5A protein, His-tagged | E.coli | Human | His | 422-714 aa | |
| SCN5A-5268R | Recombinant Rat SCN5A Protein | Mammalian Cell | Rat | His |
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| SCN5A-13H | Recombinant Human sodium voltage-gated channel alpha subunit 5 Protein, His tagged | E. coli | Human | His | 450-650aa |
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| SCN5A-15HFL | Recombinant Full Length Human sodium voltage-gated channel alpha subunit 5A Protein, GST tagged | Wheat Germ | Human | GST | Full L. 1-2016aa |
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| SCN5A-2538H | Recombinant Human SCN5A protein, His-tagged | E. coli | Human | His | Gln421-Val600 |
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| SCN5A-4927R | Recombinant Rat SCN5A Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| SCN5A-4927R-B | Recombinant Rat SCN5A Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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Involved Pathway
SCN5A involved in several pathways and played different roles in them. We selected most pathways SCN5A participated on our site, such as Adrenergic signaling in cardiomyocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with SCN5A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adrenergic signaling in cardiomyocytes | ADCY2B,ATF4B1,AKT2,MAPK12,CREB3,MAPK14A,PPP1CB,PRKCA,SCN1BA,CALM3A |
Protein Function
SCN5A has several biochemical functions, for example, ankyrin binding,calmodulin binding,enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SCN5A itself. We selected most functions SCN5A had, and list some proteins which have the same functions with SCN5A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| voltage-gated sodium channel activity | SCN1BB,HCN4,SCN8A,SCN8AB,SCN4AA,SCN1B,SCN9A,SCN1LAB,SCN2A,SCN8AA |
| calmodulin binding | ORAI1,RIT2,MARCKS,MAP2,TRPC2,RGS16,GEM,UBR4,CNN2,MYH1E |
| voltage-gated sodium channel activity involved in cardiac muscle cell action potential | SCN3B,SCN1B,SCN2B |
| ankyrin binding | SPTBN1,FLNC,PTBP3,CDH1,PLEC,KCNJ11,SLC4A1,RHAG,NRCAM,SLC8A1 |
| nitric-oxide synthase binding | ACTB,SLC14A2,CAMK2D,CAV3,SNTA1,CALM3,ATP2B4,DMD,CAV1,CALM1 |
| voltage-gated sodium channel activity involved in Purkinje myocyte action potential | SCN1B |
| protein kinase binding | SREBF1,MAPK6,NPR1,HDAC7,PLCG1,PAX6,DBF4B,ATG13,ACTA2,SPDYA |
| protein domain specific binding | TBL1X,NCK1,XPO1,TRIM11,WNT3,FOXA1,CALM2,EHD2,HAND2,NF2 |
| scaffold protein binding | KCNH2,IKBKB,HOMER1,DLG4,ADCY6,SRC,NLGN3,KRT15,SHANK3,KCNA5 |
Interacting Protein
SCN5A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SCN5A here. Most of them are supplied by our site. Hope this information will be useful for your research of SCN5A.
CAMK2D;CALM1;PTPN3
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References
- Tarradas, A; Selga, E; et al. A Novel Missense Mutation, I890T, in the Pore Region of Cardiac Sodium Channel Causes Brugada Syndrome. PLOS ONE 8:-(2013).
- Kaur, K; Zarzoso, M; et al. TGF-beta 1, Released by Myofibroblasts, Differentially Regulates Transcription and Function of Sodium and Potassium Channels in Adult Rat Ventricular Myocytes. PLOS ONE 8:-(2013).
