SCN2B
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Official Full Name
sodium channel, voltage-gated, type II, beta -
Overview
forms a voltage gated sodium channel with alpha subunit; may modulate sodium channel expression in neurons -
Synonyms
SCN2B;sodium channel, voltage-gated, type II, beta;sodium channel subunit beta-2;Neuronal voltage gated sodium channel beta 2 subunit;Scn 2b;SCN2B_HUMAN;Sodium channel beta 2 subunit;Sodium channel subunit beta 2;Sodium channel voltage gated type II beta;Sodium channel voltage gated type II beta polypeptide;Sodium channel beta 2;sodium channel, voltage-gated, type II, beta polypeptide;SCNB2
Recombinant Proteins
- Human
- Rhesus macaque
- Zebrafish
- Rat
- E.coli
- Human Cell
- Wheat Germ
- Mammalian Cell
- HEK293
- E.coli expression system
- In Vitro Cell Free System
- GST
- His
- Non
- Fc
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SCN2B-2536H | Recombinant Human SCN2B, GST-tagged | E.coli | Human | GST | 28-160aa | |
| SCN2B-310H | Recombinant Human SCN2B, His tagged | Human Cell | Human | His | 1-159 a.a. |
|
| SCN2B-31351TH | Recombinant Human SCN2B | Wheat Germ | Human | Non | 215 amino acids |
|
| SCN2B-4100R | Recombinant Rhesus monkey SCN2B Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| SCN2B-4815Z | Recombinant Zebrafish SCN2B | Mammalian Cell | Zebrafish | His |
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| SCN2B-5263R | Recombinant Rat SCN2B Protein | Mammalian Cell | Rat | His |
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| SCN2B-697H | Recombinant Human SCN2B Protein, His-tagged | E.coli | Human | His |
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| SCN2B-8616H | Recombinant Human SCN2B protein, hFc-tagged | HEK293 | Human | Fc | Met1-Ala159 |
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| SCN2B-1280HCL | Recombinant Human SCN2B cell lysate | Human Cell | Human | Non |
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| SCN2B-975HCL | Recombinant Human SCN2B cell lysate | Human Cell | Human | Non |
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| RFL18899HF | Recombinant Full Length Human Sodium Channel Subunit Beta-2(Scn2B) Protein, His-Tagged | E.coli expression system | Human | His | Full L. Full Length of Mature Protein (30-215) |
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| RFL32011RF | Recombinant Full Length Rat Sodium Channel Subunit Beta-2(Scn2B) Protein, His-Tagged | E.coli expression system | Rat | His | Full L. Full Length of Mature Protein (30-215) |
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| SCN2B-3917R | Recombinant Rhesus Macaque SCN2B Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| SCN2B-3917R-B | Recombinant Rhesus Macaque SCN2B Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| SCN2B-457HF | Recombinant Full Length Human SCN2B Protein | In Vitro Cell Free System | Human | Full L. 215 amino acids |
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| SCN2B-4922R | Recombinant Rat SCN2B Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| SCN2B-4922R-B | Recombinant Rat SCN2B Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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Involved Pathway
SCN2B involved in several pathways and played different roles in them. We selected most pathways SCN2B participated on our site, such as Axon guidance,Developmental Biology,Interaction between L1 and Ankyrins, which may be useful for your reference. Also, other proteins which involved in the same pathway with SCN2B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| L1CAM interactions | CNTN1,NRP1A,SDCBP,NADL1.1,RANBP9,KIF4A,SCN9A,DLG3,DPYSL2,SCN8A |
| Developmental Biology | CACNG2B,SEMA3A,PSPN,MED8,PLXNC1,DAB2IPB,ACTR3,EPHA2,SCN8A,CLTC |
| Interaction between L1 and Ankyrins | KCNQ2,NADL1.1,SCN3B,ANK2B,SCN8A,SCN9A,SCN2A,KCNQ3,SCN4A,SCN3A |
| Axon guidance | EPHA1,EPHA3,CNTN6,RHOB,RASA1,SPRED2,EPHB6,ACTR2B,SEMA4C,DPYSL5 |
Protein Function
SCN2B has several biochemical functions, for example, sodium channel regulator activity,voltage-gated sodium channel activity involved in cardiac muscle cell action potential. Some of the functions are cooperated with other proteins, some of the functions could acted by SCN2B itself. We selected most functions SCN2B had, and list some proteins which have the same functions with SCN2B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| voltage-gated sodium channel activity involved in cardiac muscle cell action potential | SCN5A,SCN1B,SCN3B |
| sodium channel regulator activity | FXYD3,YWHAH,FXYD2,SGK1,SCN3B,GPD1L,PRSS30,SCN1B,SCN1BB,SCN1BA |
Interacting Protein
SCN2B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SCN2B here. Most of them are supplied by our site. Hope this information will be useful for your research of SCN2B.
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References
- Whitaker, WRJ; Faull, RLM; et al. Comparative distribution of voltage-gated sodium channel proteins in human brain. MOLECULAR BRAIN RESEARCH 88:37-53(2001).
- Szpyt, J; Lorenzon, N; et al. Three-Dimensional Localization of the alpha and beta Subunits and of the II-III Loop in the Skeletal Muscle L-type Ca2+ Channel. JOURNAL OF BIOLOGICAL CHEMISTRY 287:43853-43861(2012).
