SCN11A
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Official Full Name
sodium channel, voltage-gated, type XI, alpha subunit -
Overview
Voltage-gated sodium channels are membrane protein complexes that play a fundamental role in the rising phase of the;action potential in most excitable cells. Alpha subunits, such as SCN11A, mediate voltage-dependent gating and;conductance, while auxiliary beta subunits regulate the kinetic properties of the channel and facilitate membrane;localization of the complex. Aberrant expression patterns or mutations of alpha subunits underlie a number of;disorders. Each alpha subunit consists of 4 domains connected by 3 intracellular loops; each domain consists of 6;transmembrane segments and intra- and extracellular linkers. -
Synonyms
SCN11A;sodium channel, voltage-gated, type XI, alpha subunit;SCN12A, sodium channel, voltage gated, type XI, alpha polypeptide , sodium channel, voltage gated, type XII, alpha;sodium channel protein type 11 subunit alpha;NaN;Nav1.9;SNS 2;hNaN;Peripheral nerve sodium channel 5;PN 5;PN5;SCN 11A;SCN 12A;SCN12A;Sensory neuron sodium channel 2;SNS2;Sodium channel protein type XI subunit alpha;Sodium channel voltage gated type XI alpha;Sodium channel voltage gated type XI alpha polypeptide;Sodium channel voltage gated type XI alpha subunit;Sodium channel voltage gated type XII alpha polypeptide;Voltage gated sodium channel Nav1.9;Voltage gated sodium channel subunit alpha Nav1.9;OTTHUMP00000045937;OTTHUMP00000209286;OTTHUMP00000209287;voltage-gated sodium channel Nav1.9;sodium channel protein type XI subunit alp;SNS-2
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Mammalian Cell
- HEK293
- His
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SCN11A-3910H | Recombinant Human SCN11A protein, His-tagged | E.coli | Human | His | 812-1051 aa | |
| SCN11A-14752M | Recombinant Mouse SCN11A Protein | Mammalian Cell | Mouse | His |
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| SCN11A-5259R | Recombinant Rat SCN11A Protein | Mammalian Cell | Rat | His |
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| SCN11A-4918R | Recombinant Rat SCN11A Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| SCN11A-4918R-B | Recombinant Rat SCN11A Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| SCN11A-7937M | Recombinant Mouse SCN11A Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| SCN11A-7937M-B | Recombinant Mouse SCN11A Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
SCN11A involved in several pathways and played different roles in them. We selected most pathways SCN11A participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SCN11A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
SCN11A has several biochemical functions, for example, ion channel activity,protein binding,sodium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SCN11A itself. We selected most functions SCN11A had, and list some proteins which have the same functions with SCN11A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | NSMCE4A,AGTRAP,HPRT1,CTDSP2,RHNO1,EPN2,NAPRT1,P4HB,SOX7,NEK8 |
| voltage-gated ion channel activity | KCNV2B,CLIC2,KCNA6A,KCNH5,KCNS3A,KCNB2,TRPM5,CLIC5B,KCNJ1A.3,TMEM37 |
| sodium channel activity | SCN8AB,ASIC1B,ASIC4,SCN8AA,SCN4AB,ACCN4,SCN12AA,ASIC1C,SCNN1G,TRPM5 |
| voltage-gated sodium channel activity | SCN4AA,SCN8AA,SCN1B,SCN2A,HCN4,SCN1LAB,SCN5A,SCN3A,SCN12AA,SCN9A |
| ion channel activity | KCNG4A,KCNC3B,TRPC4A,CHRNB3B,TRPC7B,TRPA1A,GJC1,FXYD6L,CHRNB1L,KCNS3B |
Interacting Protein
SCN11A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SCN11A here. Most of them are supplied by our site. Hope this information will be useful for your research of SCN11A.
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