SARS
-
Official Full Name
seryl-tRNA synthetase -
Overview
Severe acute respiratory syndrome (SARS) is a viral respiratory illness caused by a coronavirus, called SARS-associated coronavirus (SARS-CoV). Human coronaviruses (HCoVs) were previously only associated with mild diseases. The SARS-CoV genome contains five major open reading frames (ORFs) that encode the replicase polyprotein; the spike (S), envelope (E), and membrane (M) glycoproteins; and the nucleocapsid protein (N). -
Synonyms
SARS;seryl-tRNA synthetase;serine--tRNA ligase, cytoplasmic;serine tRNA ligase 1;cytoplasmic;SERS;Seryl-tRNA Ser/Sec synthetase;seryl-tRNA(Ser/Sec) synthetase;serine tRNA ligase 1, cytoplasmic;seryl-tRNA synthetase, cytoplasmic;SERRS;FLJ36399
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Chicken
- Rat
- Cynomolgus
- SARS
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- Mouse
- In Vitro Cell Free System
- HEK293T
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
SARS involved in several pathways and played different roles in them. We selected most pathways SARS participated on our site, such as Aminoacyl-tRNA biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SARS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Aminoacyl-tRNA biosynthesis | MADD,DARS,IARS,AARS,GATC,NARS,PSTK,IARS2,MARS2,MTFMT |
Protein Function
SARS has several biochemical functions, for example, ATP binding,RNA binding,serine-tRNA ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SARS itself. We selected most functions SARS had, and list some proteins which have the same functions with SARS. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA binding | EIF2C3,RAVER2,IFIT14,MIF4GDA,TRIM71,ZNF74,AGO3B,CELF5,ATXN2,ZNF239 |
| ATP binding | TNK1,CSNK1G2B,HSPH1,DALRD3,PDXK,MYH1B,IGHMBP2,PRKX,ADCY6,TTLL6 |
| serine-tRNA ligase activity | SARS2 |
Interacting Protein
SARS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SARS here. Most of them are supplied by our site. Hope this information will be useful for your research of SARS.
ORF;GH1;HLA-C;SIRT2;UBA5;FTSJ1;TNIK;TERF1;TINF2;POT1;ere_dna;MYC;VCAM1;Kif22;Tmed10
Resources
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References
- Honda-Okubo, Y; Barnard, D; et al. Severe Acute Respiratory Syndrome-Associated Coronavirus Vaccines Formulated with Delta Inulin Adjuvants Provide Enhanced Protection while Ameliorating Lung Eosinophilic Immunopathology. JOURNAL OF VIROLOGY 89:2995-3007(2015).
- Lau, SKP; Woo, PCY; et al. Discovery of a Novel Coronavirus, China Rattus Coronavirus HKU24, from Norway Rats Supports the Murine Origin of Betacoronavirus 1 and Has Implications for the Ancestor of Betacoronavirus Lineage A. JOURNAL OF VIROLOGY 89:3076-3092(2015).
