SAMHD1
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Official Full Name
SAM domain and HD domain 1 -
Overview
SAM domain and HD domain-containing protein 1 (SAMHD1) is a putative nuclease involved in innate immune response by acting as a negative regulator of the cell-intrinsic antiviral response. SAMHD1 may play a role in mediating proinflammatory responses to T -
Synonyms
SAMHD1;SAM domain and HD domain 1;SAM domain and HD domain-containing protein 1;AGS5;Aicardi Goutieres syndrome 5;HD domain containing 1;HDDC1;Mg11;monocyte protein 5;MOP 5;SBBI88;dendritic cell-derived IFNG-induced protein;DCIP;CHBL2;MOP-5
Recombinant Proteins
- Human
- Chicken
- Rhesus macaque
- Zebrafish
- Cynomolgus
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- Mammalian cells
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
- Flag
Involved Pathway
SAMHD1 involved in several pathways and played different roles in them. We selected most pathways SAMHD1 participated on our site, such as Cytokine Signaling in Immune system,Immune System,Interferon Signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with SAMHD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Interferon Signaling | IFITM2,TRIM38,OASL,TRIM17,ARIH1,GBP6,XAF1,TRIM3,ISG20,TRIM62 |
| Cytokine Signaling in Immune system | FCGR1B,JAK3,EDARADD,LGALS9,GBP1,CSF2,IFIT12,NUPL2,HLA-DQB2,FRS2A |
| Immune System | SPSB2,TRIM6,ERAP1,TRIM39,SPSB1,ASB7,EDA,IRF9,UNC93B1,DEFB4A |
| Interferon alpha/beta signaling | IRF2,OASL,IRF6,IFI27,GBP2,USP18,IFI6,IFITM2,IRF4,MX2 |
Protein Function
SAMHD1 has several biochemical functions, for example, RNA binding,dGTP binding,dGTPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SAMHD1 itself. We selected most functions SAMHD1 had, and list some proteins which have the same functions with SAMHD1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| zinc ion binding | TRIM16,KDM5BA,ABLIM3,TRIM5,RP9,CAPNS2,INTS12,RNF207,CPZ,RBM4B |
| RNA binding | CDKN2AIP,RBFOX1L,RPP14,RBM4B,IGHMBP2,RPL15,RBM12B2,HBP1,DPPA5A,SETD1BA |
| protein binding | MICALL1,BCKDHB,FPR1,AGTR1,SLMAP,FUT11,TRIM15,PHOSPHO2,SMAD7,F10 |
| nucleic acid binding | ZFP131,NTNG1,ZNF143A,PABPC1B,PLAGL2,BCL11AA,TDRD9,ZBTB16A,TRERF1,ZNFL1 |
Interacting Protein
SAMHD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SAMHD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SAMHD1.
DYSF;TIRAP;vpx;PHLDA3;1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate;SF1;SMARCD2;SOGA1;PPP2R1A;AKAP12;STX3;SF1;PPP2R5E;HSF5;LRRK2;GPATCH4;RSBN1L
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References
- Chauveau, L; Puigdomenech, I; et al. HIV-2 infects resting CD4+T cells but not monocyte-derived dendritic cells. RETROVIROLOGY 12:-(2015).
- Riveira-Munoz, E; Ruiz, A; et al. Increased expression of SAMHD1 in a subset of HIV-1 elite controllers. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 69:3057-3060(2014).
