SAFB
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Official Full Name
scaffold attachment factor B -
Overview
This gene encodes a DNA-binding protein which has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. The encoded protein is thought to serve as a molecular base to assemble a transcriptosome complex in the vicinity of actively transcribed genes. It is involved in the regulation of heat shock protein 27 transcription, can act as an estrogen receptor co-repressor and is a candidate for breast tumorigenesis. This gene is arranged head-to-head with a similar gene whose product has the same functions. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
SAFB;scaffold attachment factor B;scaffold attachment factor B1;HET;Hsp27 ERE TATA binding protein;SAFB1;SAF-B;SAB-B1;HSP27 ERE-TATA-binding protein;Hsp27 ERE-TATA binding protein;glutathione S-transferase fusion protein;HSP27 estrogen response
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rat
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- GST
- His
- Non
- His&GST
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SAFB-2500H | Recombinant Human SAFB, GST-tagged | E.coli | Human | GST | 58-213aa | |
| SAFB-2597H | Recombinant Human SAFB protein, His-tagged | E.coli | Human | His | 58-213 aa | |
| SAFB-12714Z | Recombinant Zebrafish SAFB | Mammalian Cell | Zebrafish | His |
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| SAFB-14642M | Recombinant Mouse SAFB Protein | Mammalian Cell | Mouse | His |
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| SAFB-29263TH | Recombinant Human SAFB | Wheat Germ | Human | Non | 90 amino acids |
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| SAFB-5224R | Recombinant Rat SAFB Protein | Mammalian Cell | Rat | His |
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| Safb-2042M | Recombinant Mouse Safb Protein, His&GST-tagged | E.coli | Mouse | His&GST | Ala2-Ser235 |
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| SAFB-4883R | Recombinant Rat SAFB Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| SAFB-4883R-B | Recombinant Rat SAFB Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| SAFB-7884M | Recombinant Mouse SAFB Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| SAFB-7884M-B | Recombinant Mouse SAFB Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
SAFB involved in several pathways and played different roles in them. We selected most pathways SAFB participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SAFB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
SAFB has several biochemical functions, for example, chromatin binding,core promoter binding,double-stranded DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SAFB itself. We selected most functions SAFB had, and list some proteins which have the same functions with SAFB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | RPL24,POLR2A,MBNL2,MAGOH2,SRPK2,PTCD3,EFTUD2,NPM3,RPS5,MRPL27 |
| core promoter binding | MTF1,NEUROG3,INSM1A,CLOCK,HNRNPU,CRY1,HMGA2,GADD45A,E2F1,CCAR1 |
| chromatin binding | NFKB1,HDAC2,MLL1,APBB1,RBMX,PRMT6,ZEB1,TOX2,NR5A1B,HMGXB4A |
| double-stranded DNA binding | NTHL1,FEN1,FEV,IFI16,ZNF638,EGFR,MTERF,RAD51L1,SATB1,CRY1 |
| nucleotide binding | DNAHC8,ATP2B1,SRSF7B,SYNCRIP,PTBP2A,ABCC8,SBK3,RHOAC,HINT1,NME2A |
| protein binding | TAL2,FAP,TP53RK,RAB11FIP2,TRIM16,SPP1,PDLIM2,TERF1,GALR1,VEGFA |
Interacting Protein
SAFB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SAFB here. Most of them are supplied by our site. Hope this information will be useful for your research of SAFB.
TP53;MAP1LC3B;SRPK1;SRPK1;SAFB2;Srek1;CSNK2A1;EEF1D
Resources
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References
- Schwaiger, E; Wahrmann, M; et al. Complement Component C3 Activation: The Leading Cause of the Prozone Phenomenon Affecting HLA Antibody Detection on Single-Antigen Beads. TRANSPLANTATION 97:1279-1285(2014).
- Guidicelli, G; Anies, G; et al. The complement interference phenomenon as a cause for sharp fluctuations of serum anti-HLA antibody strength in kidney transplant patients. TRANSPLANT IMMUNOLOGY 29:17-21(2013).
Reviews
Q&As
Thank you for your interest in our product. The MW of SAFB-2597H is 35KDa.