SAE1
-
Official Full Name
SUMO1 activating enzyme subunit 1 -
Overview
The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. -
Synonyms
SAE1;SUMO1 activating enzyme subunit 1;SUMO-activating enzyme subunit 1;activator Of sumo 1;AOS1;FLJ3091;Sua1;activator of SUMO1;SUMO-1 activating enzyme subunit 1;sentrin/SUMO-activating protein AOS1;SUMO-1 activating enzyme E1 N subunit;ubiquitin-like 1-activating enzyme E1A;ubiquitin-like protein SUMO-1 activating enzyme;UBLE1A;HSPC140
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rat
- E.coli
- Human
- Mammalian Cell
- Sf9 Insect Cell
- Insect Cell
- Insect Cells
- HEK293T
- HEK293
- Mammalian cells
- GST
- His
- His&GST
- Non
- Myc&DDK
- His&Fc&Avi
- Flag
Involved Pathway
SAE1 involved in several pathways and played different roles in them. We selected most pathways SAE1 participated on our site, such as Metabolism of proteins,Post-translational protein modification,Processing and activation of SUMO, which may be useful for your reference. Also, other proteins which involved in the same pathway with SAE1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ubiquitin mediated proteolysis | NEDD4L,FLJ11011L,DET1,UBE2IB,SOCS1A,FZR1A,CDC27,UBR5,SIAH1A,UBE2KB |
| Post-translational protein modification | TRAPPC4,A4GNT,GALNT13,ARSE,LMAN2L,ADAMTSL1,SMC5,MUC13,DPAGT1,B3GNT8 |
| SUMO is transferred from E1 to E2 (UBE2I, UBC9) | UBA2 |
| Processing and activation of SUMO | SENP5,UBA2,SENP1 |
| SUMOylation | CBX8,SENP5,SCMH1,SENP1,PHC1,UBA2,PHC3,NSMCE1,RING1,NSMCE2 |
| SUMO is conjugated to E1 (UBA2:SAE1) | UBA2 |
| Metabolism of proteins | CCT6A,BCS1L,APCS,GRP,IGFBP2B,NSMCE2,NAT8B,ADD1,ADAMTS10,ADAMTSL4 |
Protein Function
SAE1 has several biochemical functions, for example, ATP-dependent protein binding,contributes_to SUMO activating enzyme activity,enzyme activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SAE1 itself. We selected most functions SAE1 had, and list some proteins which have the same functions with SAE1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein heterodimerization activity | TBX15,TAS1R1,FZD9,DR1,FZD1,TIRAP,ABTB2,RXRA,POLA1,H2AFB1 |
| enzyme activator activity | TAB1,APOA5,CTAGE5,CLPSL1,TIMP2,UBA2,TRIM23,RAB3GAP2,PRKCD,DAOA |
| protein C-terminus binding | AGO2,MKI67,MAP3K7,AP2A1,HPCAL4,CLIC6,ERCC4,MAPRE1,PABPC1,SNX17 |
| ATP-dependent protein binding | DDX39B,MYO5A,PRNP,DNAJC5,STX1A |
| ubiquitin activating enzyme activity | UBE1Y1,UBA1,UBA7,ATG7,UBA6 |
| protein binding | MED7,ALDH18A1,EHD2,PASK,AZIN1,NPBWR2,CAMP,SORBS2,ELMO3,GP1BB |
Interacting Protein
SAE1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SAE1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SAE1.
UBA2;UBE2I;TP53;40068515;SUMO3;SUMO1;FKBP4;IKBKE;CYP1B1;TRAF6;IL3RA;PTK2;truB
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