RRM1
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Official Full Name
ribonucleotide reductase M1 -
Overview
Ribonucleotide reductase M1 polypeptide (RRM1) is one of two non-identical subunits for ribonucleoside-diphosphate reductase, an enzyme which catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RRM1 is present throughout the cell division cycle but downregulated in quiescent cells. RRM1 is involved in carcinogenesis, tumor progression, and the response of non-small-cell lung cancer (NSCLC) to chemotherapy. -
Synonyms
RRM1;ribonucleotide reductase M1;ribonucleotide reductase M1 polypeptide;ribonucleoside-diphosphate reductase large subunit;ribonucleotide reductase, R1 subunit;ribonucleotide reductase, large subunit;ribonucleoside-diphosphate reductase subunit M1;R1;RR1;RIR1
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rhesus macaque
- Zebrafish
- E.coli
- Mammalian Cell
- Wheat Germ
- Insect Cell
- Insect Cells
- Yeast
- Mammalian cells
- HEK293
- HEK293T
- GST
- His
- Non
- His&GST
- Flag
- His&Fc&Avi
- Myc&DDK
- His&SUMO
Involved Pathway
RRM1 involved in several pathways and played different roles in them. We selected most pathways RRM1 participated on our site, such as Purine metabolism,Pyrimidine metabolism,Glutathione metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with RRM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glutathione metabolism | GSS,GSTM1,MGST3,GSTA5,LAP3,GSTO1,GSTP2,GSTA2,GSTA1,ODC1 |
| Metabolic pathways | ALDH3A1,AKR1B10,HMGCS1,POLR2I,CDA,CYP2P6,COX5B,XYLT1,SYNJ2,GULO |
| Purine metabolism | PNP5B,NT5M,POLE2,ENTPD4,PDE11A,GMPR,ENTPD2A.1,IMPDH2,POLR3E,ENTPD5 |
| Pyrimidine metabolism | TYMP,POLE,UMPS,NME7,POLR3GL,TK1,NT5C2B,NT5E,POLR1C,POLR2F |
Protein Function
RRM1 has several biochemical functions, for example, ATP binding,protein binding,ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Some of the functions are cooperated with other proteins, some of the functions could acted by RRM1 itself. We selected most functions RRM1 had, and list some proteins which have the same functions with RRM1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | BLK,RALB,EPB42,TBCB,METTL9,APOBEC1,NAPB,SEC61B,GTF2F2,CASP2 |
| ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor | RRM2B,RRM2 |
| ATP binding | ATP12A,SLC27A5,MYO9B,DNAJA1,STK17A,CSNK1DA,MYO3B,EGFR,HSP90B1,NRK |
Interacting Protein
RRM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RRM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RRM1.
RRM2;MCC;HLA-B;EIF6;IKBKE;ATG5;FTSJ1;TNIK;PRKAB1;PPP1CC;RIF1;15-deoxy-delta(12,14;Ubr5;MYC;RNASEH2B;Cdca8;Cdkn2aip
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References
- Langer, CJ; et al. Exploring biomarkers in head and neck cancer. CANCER 118:3882-3892(2012).
- Shodai, A; Morimura, T; et al. Aberrant Assembly of RNA Recognition Motif 1 Links to Pathogenic Conversion of TAR DNA-binding Protein of 43 kDa (TDP-43). JOURNAL OF BIOLOGICAL CHEMISTRY 288:14886-14905(2013).
