RORA
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Official Full Name
RAR-related orphan receptor A -
Overview
The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Also, it has been shown to aid in the transcriptional regulation of some genes involved in circadian rhythm. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2014] -
Synonyms
RORA;RAR-related orphan receptor A;ROR1;ROR2;ROR3;RZRA;NR1F1;RZR-ALPHA;nuclear receptor ROR-alpha;ROR-alpha;nuclear receptor RZR-alpha;transcription factor RZR-alpha;retinoid-related orphan receptor alpha;nuclear receptor subfamily 1 group F member 1;thyroid hormone nuclear receptor alpha variant 4;retinoic acid receptor-related orphan receptor alpha
Recombinant Proteins
- Human
- Chicken
- Mouse
- HEK293
- Sf9 Cells
- E.coli
- Mammalian Cells
- Insect Cells
- Wheat Germ
- Yeast
- In Vitro Cell Free System
- Myc&DDK
- GST
- His&T7
- His
- Non
- His&Fc&Avi
- Flag
- His&SUMO
- SUMO
Involved Pathway
RORA involved in several pathways and played different roles in them. We selected most pathways RORA participated on our site, such as Circadian rhythm,Inflammatory bowel disease (IBD), which may be useful for your reference. Also, other proteins which involved in the same pathway with RORA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Inflammatory bowel disease (IBD) | STAT4,NFATC1,IL12A,HLA-DOB,IL17F,IFNGR2,HLA-DRB3,IL2RG,H2-AA,STAT6 |
| Circadian rhythm | RORB,CLOCK,SKP1,CRY2,RBX1,NR1D1,PRKAB1,PRKAG3,ARNTL,PER3 |
Protein Function
RORA has several biochemical functions, for example, DNA binding,RNA polymerase II regulatory region sequence-specific DNA binding,RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RORA itself. We selected most functions RORA had, and list some proteins which have the same functions with RORA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| core promoter sequence-specific DNA binding | PRMT5,MLL1,MEOX1,SP1,H2AFY,THRAP3,ZFHX3,MTA1,NRIP1,KLF10 |
| transcription coactivator binding | PASD1,TERT,ZBTB49,NR4A3 |
| DNA binding | NEUROD4,HIST1H4K,MEIOB,ZNF2,HMGXB3,HIST1H2AO,ZFP319,POLR2EB,ZNF177,POU2AF1 |
| protein binding | FCNA,FATE1,NECAB2,SSNA1,PLGRKT,NFKBID,MRPL10,NRXN1,SSBP3,NAT8 |
| RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding | PPARDB,NR4A2A,RORCA,NR1I2,NR5A1B,RORC,PPARAA,VDRA,RORCB,ESR2 |
| transcription factor activity, sequence-specific DNA binding | SPZ1,KLF17,CNOT7,ZFP287,TLX2,TRP63,MYCLB,GTF2IRD1,POU2F1A,GATAD2B |
| transcription factor activity, direct ligand regulated sequence-specific DNA binding | RORC |
| sequence-specific DNA binding | FOXC2,FOXD4L1,NR6A1,KLF5,TFAP2A,NFYBA,RREB1,POU2F3,GLI1,MSXC |
| transcription corepressor binding | NR1D1,FAM89B,HDGF,SIX3 |
Interacting Protein
RORA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RORA here. Most of them are supplied by our site. Hope this information will be useful for your research of RORA.
GFAP;PSMC5;NR0B1;NCOA1;LMO3;Bhlhe41;Csnk1e;st2a1_human_gene
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