RNF7
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Official Full Name
ring finger protein 7 -
Overview
The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported. -
Synonyms
RNF7;ring finger protein 7;SAG;ROC2;CKBBP1;sensitive to apoptosis, zinc RING finger protein SAG, regulator of cullins 2;RING-box protein 2;Rbx2;CKII beta-binding protein 1;Regulator of cullins 2;Sensitive to apoptosis gene protein;OTTHUMP00000180644;OTTHUMP00000180645;zinc RING finger protein SAG
Recombinant Proteins
- Mouse
- Zebrafish
- Human
- Chicken
- Rhesus macaque
- Mammalian Cell
- E.coli
- HEK293
- Yeast
- HEK293T
- His
- Myc&DDK
- Non
- His&Fc&Avi
- GST
Involved Pathway
RNF7 involved in several pathways and played different roles in them. We selected most pathways RNF7 participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with RNF7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ubiquitin mediated proteolysis | RHOBTB2A,FZR1A,KEAP1,TRIM37,CUL3B,FLJ11011L,PARK2,UBE4B,UBE2KA,ANAPC2 |
Protein Function
RNF7 has several biochemical functions, for example, NEDD8 transferase activity,copper ion binding,cullin family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RNF7 itself. We selected most functions RNF7 had, and list some proteins which have the same functions with RNF7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | RABGEF1,SENP1,MRFAP1,SNRPC,PFKFB2,TNPO1,ESD,FNTA,NGDN,ARHGAP33 |
| ubiquitin protein ligase activity | CBL,MED21,NEURL3,ANKIB1A,TRIM71,RAD18,UBE3B,UBR2,UBE2KB,RNF144B |
| copper ion binding | CP,COX17,S100A5,SOD1,TYR,APOA4,TRP53,DCT,HAMP,AOC3 |
| zinc ion binding | SETMAR,DPYS,DUSP12,PDLIM3B,ZDHHC15,RNF34,CPA6,BTR22,ZNF185,ACE |
| cullin family protein binding | DCUN1D1,ANAPC11,TCHP,DCUN1D2A,CCDC22,DCUN1D2B,DCUN1D5,RBX1,KCTD17,DCUN1D3 |
| NEDD8 transferase activity | UBE2F,RBX1,UBE2M |
Interacting Protein
RNF7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RNF7 here. Most of them are supplied by our site. Hope this information will be useful for your research of RNF7.
CUL5;IKBKG;vif;RAB40C;ASB12;ASB2;ASB7;ASB6;ASB1;UBE2D1
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References
- Zhou, WH; Xu, J; et al. SAG/RBX2 is a novel substrate of NEDD4-1 E3 ubiquitin ligase and mediates NEDD4-1 induced chemosensitization. ONCOTARGET 5:6746-6755(2014).
- Sahun, I; Marechal, D; et al. Cognition and Hippocampal Plasticity in the Mouse Is Altered by Monosomy of a Genomic Region Implicated in Down Syndrome. GENETICS 197:899-912(2014).
