RNF34
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Official Full Name
ring finger protein 34, E3 ubiquitin protein ligase -
Overview
The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported. -
Synonyms
RNF34;ring finger protein 34, E3 ubiquitin protein ligase;ring finger protein 34;E3 ubiquitin-protein ligase RNF34;FLJ21786;RIF;RIFF;caspase regulator CARP1;RING finger protein RIFF;FYVE-RING finger protein MOMO;caspases-8 and -10-associated RIN
Recombinant Proteins
- Human
- Chicken
- Mouse
- Rhesus macaque
- Rat
- Insect Cell
- Mammalian Cell
- E.coli
- HEK293
- HEK293T
- GST
- His
- Myc&DDK
- Non
- His&Fc&Avi
Involved Pathway
RNF34 involved in several pathways and played different roles in them. We selected most pathways RNF34 participated on our site, such as Adaptive Immune System,Antigen processing: Ubiquitination &,Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with RNF34 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Antigen processing: Ubiquitination & | RNF14,KLHL21,ASB17,ASB13,UBE2J2,RNF19B,ASB7,RNF144B,UBE2L6,ASB8 |
| Proteasome degradation | BLMH,FBXO3,STUB1,UBE2U,ARIH2,UBE2E3,RNF14,RNF182,ASB4,DTX3L |
| Adaptive Immune System | LILRB2,CD300LG,LILRB4,IGLC2,KLHL20,ARIH2,CTSE,KIF3A,LRRC41,KIF20A |
| presentation | ASB8,HUWE1,SH3RF1,CD207,DZIP3,FBXO44,CTSS,LRR1,UBE2L6,RNF182 |
| Immune System | RNF138,CD200R3,MGC174152,DTX3L,GBP5,CASPB,ALCAMB,GRAP2B,PJA1,PLD4 |
| Class I MHC mediated antigen processing & | UBE2J2,ASB14,RNF6,ERAP2,SPSB4,STUB1,TRIM50,FCGR1B,RNF138,ARIH2 |
Protein Function
RNF34 has several biochemical functions, for example, ligase activity,p53 binding,phosphatidylinositol phosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RNF34 itself. We selected most functions RNF34 had, and list some proteins which have the same functions with RNF34. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | SMARCC2,DPH1,XRCC6,POLG2,PRL,KCNG4,ENPP1,CD44,MYH11,POLD1 |
| ubiquitin protein ligase binding | KDM4A,CASC3,GRIK2,UBE2G1A,MOAP1,LTBR,UBE2J1,FZD6,PPARGC1A,WFS1 |
| ligase activity | MDM2,RNF40,CTPS1A,UBE2D1B,RNF38,ACSM2,UBE2CBP,RNF111,TRIM56,ZNRF1 |
| phosphatidylinositol phosphate binding | SNX11,RPH3A,ANKFY1,GAP43,PLCD1 |
| p53 binding | TRIM24,DUSP26,TAF3,SIRT1,BANP,USP10,ZMAT3,TP63,TAF9,NTRK3 |
| ubiquitin protein ligase activity | DZIP3,CDC34B,TMEM189,XIAP,CBLC,HERC4,UBE2R2,RNF14,CBL,BFAR |
| zinc ion binding | RNF39,RFPL2,SRSF7,RNF17,TOPORS,ZCCHC8,ZFR,PRKCBA,ABLIM3,APOBEC2B |
Interacting Protein
RNF34 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RNF34 here. Most of them are supplied by our site. Hope this information will be useful for your research of RNF34.
APPBP2;CASP8;UBA1;UBE2N;UBE2V1;phosphatidylinositol-3-phosphate;phosphatidylinositol;phosphatidylinositol 4-phosphates;TRIM23;UBE2H;CASP10;UBE2F;PHF7
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