RNF20

  • Official Full Name

    ring finger protein 20, E3 ubiquitin protein ligase

  • Overview

    The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. The protein encoded by this human gene is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. This protein acts as a putative tumor suppressor and positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. In contrast, this protein also suppresses the expression of several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor. This gene selectively suppresses the expression of some genes by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS). [provided by RefSeq, Feb 2012]

  • Synonyms

    RNF20;ring finger protein 20, E3 ubiquitin protein ligase;BRE1;BRE1A;hBRE1;E3 ubiquitin-protein ligase BRE1A;BRE1-A;homolog of S. cerevisiae BRE1;BRE1 E3 ubiquitin ligase homolog

Recombinant Proteins

  • Human
  • Mouse
  • Chicken
  • Rhesus macaque
  • Zebrafish
  • E.coli
  • Mammalian Cell
  • HEK293
  • GST
  • His
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
RNF20-2342H Recombinant Human RNF20, GST-tagged E.coli Human GST 96-433aa
RNF20-14330M Recombinant Mouse RNF20 Protein Mammalian Cell Mouse His
RNF20-3083C Recombinant Chicken RNF20 Mammalian Cell Chicken His
RNF20-3938R Recombinant Rhesus monkey RNF20 Protein, His-tagged Mammalian Cell Rhesus macaque His
RNF20-8115Z Recombinant Zebrafish RNF20 Mammalian Cell Zebrafish His
RNF20-1524HCL Recombinant Human RNF20 cell lysate Human Non
RNF20-3755R Recombinant Rhesus Macaque RNF20 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
RNF20-3755R-B Recombinant Rhesus Macaque RNF20 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
RNF20-7672M Recombinant Mouse RNF20 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
RNF20-7672M-B Recombinant Mouse RNF20 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    RNF20 involved in several pathways and played different roles in them. We selected most pathways RNF20 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with RNF20 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    Protein Function

    RNF20 has several biochemical functions, for example, chromatin binding,histone binding,ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RNF20 itself. We selected most functions RNF20 had, and list some proteins which have the same functions with RNF20. You can find most of the proteins on our site.

    Function Related Protein
    ubiquitin protein ligase binding ACVR1B,RALB,SMAD3,CBS,TP53,MAP1LC3C,PCBP2,SCN5A,VCL,TANK
    zinc ion binding ZDHHC15B,RC3H1,NPSN,ZCCHC24,PIAS2,ZEB1,GATA2,ADAM22,EHMT1A,ZDHHC2
    histone binding ASF1B,UIMC1,HIST1H4I,CHD2,CTSL1,PRKCBB,RAG1,HIST2H4A,HIST1H4C,HIST1H3E
    chromatin binding GLI1,Ar,ARNTL1B,HDAC2,ANKRD2,C19orf40,HDAC3,REST,SOD3,HDAC7
    ligase activity UBE2I,RNF187,UBE2D1B,PELI1,MSL2,NEDD4,TRIM56,ATG10,UBE2L3A,HUWE1
    protein binding KLC3,FAM188A,MATN4,PPP2R5E,AK3,PKP2,WDR61,RBM14,DCDC2B,GP5
    mRNA 3-UTR binding HNRNPC,TES,CIRBP,ANGEL2,LARP1,IGF2BP1,PUM2,RBM4,YBX2,SECISBP2
    transcription coactivator activity HTATIP2,TBPL1,TAF7L,TCERG1,STIL,PPARGC1A,SOX17,GABPA,TGFB1I1,TAF7
    contributes_to ubiquitin-protein transferase activity CCIN,KBTBD2,BACH2,KLHL1,BACH1,TCEB3C,KLHL42,IPP,KLHL13,KEAP1

    Interacting Protein

    RNF20 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RNF20 here. Most of them are supplied by our site. Hope this information will be useful for your research of RNF20.

    RNF40;USHBP1;AMOTL2;HTT;UBE2A

    Resources

    Research Area

    Histone Ubiquitylation

    References

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