RNF14
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Official Full Name
ring finger protein 14 -
Overview
The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Six alternatively spliced transcript variants encoding two distinct isoforms have been reported. -
Synonyms
RNF14;ring finger protein 14;E3 ubiquitin-protein ligase RNF14;ARA54;HFB30;TRIAD2;Androgen receptor associated protein 54;Androgen receptor-associated protein 54;ARA 54;E3 ubiquitin protein ligase RNF14;FLJ26004;HFB 30;HRIHFB2038;RNF 14;RNF14_HUMAN;TRIAD 2;Triad2 protein;OTTHUMP00000160065;OTTHUMP00000160066
Recombinant Proteins
- Mouse
- Chicken
- Zebrafish
- Rhesus macaque
- Human
- Mammalian Cell
- HEK293
- E.coli
- HEK293T
- His
- Myc&DDK
- Non
- His&Fc&Avi
Involved Pathway
RNF14 involved in several pathways and played different roles in them. We selected most pathways RNF14 participated on our site, such as Adaptive Immune System,Androgen receptor signaling pathway,Antigen processing: Ubiquitination &, which may be useful for your reference. Also, other proteins which involved in the same pathway with RNF14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Androgen receptor signaling pathway | ZMIZ1,AES,KDM1A,DSTN,NR2C2,HTATIP,EFCAB6,CARM1,PATZ1,GNB2L1 |
| Proteasome degradation | DZIP3,FBXO3,HUWE1,ASB10,TRIM11,FBXO17,ASB2,WWP1,RNF144B,ASB11 |
| Adaptive Immune System | MOV10,CTSS,CTSC,RNF138,SIGLEC12,CTS7,EVL,DCTN1,KIF4,WSB1 |
| Class I MHC mediated antigen processing & | UBR1,NPEPPS,RNF19B,DZIP3,HUWE1,KLHL20,CTSL1,RNF34,TPP2,ASB6 |
| Antigen processing: Ubiquitination & | UFL1,SPSB1,UBE2U,RNF41,FBXO17,BLMH,NPEPPS,ASB10,TRIM39,TRIM41 |
| Immune System | NCKAP1,TREML2,ADAR,KIF2A,ASB13,RNF25,SEC23A,Mill2,ASB18,PPIAL4A |
| presentation | ARIH2,STUB1,ASB4,PJA2,RNF4,VPRBP,WWP1,TRIM39,TRIM63,KLHL20 |
Protein Function
RNF14 has several biochemical functions, for example, androgen receptor binding,ligase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RNF14 itself. We selected most functions RNF14 had, and list some proteins which have the same functions with RNF14. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription coactivator activity | TCF3,BRCA1,ESR2,SOX10,MED21,RNF20,MYOD1,SCAND1,PML,NFYC |
| ligase activity | UBR3,RANBP2,UHRF1,UHRF2,TRIM8,UBR1,MIB1,UBE3A,UFL1,CBL |
| ubiquitin protein ligase activity | TRIM63,RNF222,CDK8,UBE2J1,RNF144B,MYLIP,UBE2U,ARIH2,AMFR,ZSWIM2 |
| ubiquitin conjugating enzyme binding | ANKIB1,DCUN1D3,MARCH6,ARIH2,RASD2,DCUN1D2B,ZMYM2,ARIH1L,DCUN1D2A,RNF144AB |
| androgen receptor binding | NRIP1,TRIM68,DDX5,NCOA4,FOXP1,FHL2,KDM3A,CCNE1,CTNNB1,BRCA1 |
| ubiquitin-like protein transferase activity | ARIH1,RNF139,ATG3,UBL4A,ATG16L1 |
| zinc ion binding | RNF135,UNKL,LNX2B,KDM2A,ZCCHC24,TRIM74,TRIM31,KAT7,TRIM36,ZDHHC3B |
| protein binding | HCK,KDM1A,RPS6KA1,KIF3B,KLHDC4,SCYL1,CRB1,SPG7,SH2B2,IVL |
Interacting Protein
RNF14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RNF14 here. Most of them are supplied by our site. Hope this information will be useful for your research of RNF14.
UBE2D1;UBE2D4;DACH1;AR;HNF1A;UBE2E1;UBE2D3;UBE2D2;UBE2V1;FAM46A
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