RNF139
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Official Full Name
ring finger protein 139 -
Overview
The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as withCOPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP. -
Synonyms
RNF139;ring finger protein 139;E3 ubiquitin-protein ligase RNF139;HRCA1;RCA1;TRC8;multiple membrane spanning receptor TRC8;patched related protein translocated in renal cancer;translocation in renal carcinoma on chromosome 8 protein;MGC31961
Recombinant Proteins
- Mouse
- Chicken
- Rhesus macaque
- Zebrafish
- Human
- Mammalian Cell
- HEK293
- E.coli
- His
- Non
- GST
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RNF139-14302M | Recombinant Mouse RNF139 Protein | Mammalian Cell | Mouse | His |
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| RNF139-2643C | Recombinant Chicken RNF139 | Mammalian Cell | Chicken | His |
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| RNF139-3929R | Recombinant Rhesus monkey RNF139 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| RNF139-6624Z | Recombinant Zebrafish RNF139 | Mammalian Cell | Zebrafish | His |
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| RNF139-2297HCL | Recombinant Human RNF139 293 Cell Lysate | HEK293 | Human | Non |
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| RNF139-301441H | Recombinant Human RNF139 protein, GST-tagged | E.coli | Human | GST | Gln511-Asp664 |
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| RNF139-3746R | Recombinant Rhesus Macaque RNF139 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| RNF139-3746R-B | Recombinant Rhesus Macaque RNF139 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| RNF139-7652M | Recombinant Mouse RNF139 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| RNF139-7652M-B | Recombinant Mouse RNF139 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
RNF139 involved in several pathways and played different roles in them. We selected most pathways RNF139 participated on our site, such as SREBP signalling, which may be useful for your reference. Also, other proteins which involved in the same pathway with RNF139 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| SREBP signalling | DBI,INSIG2,RBP4,INSIG1,SEC23B |
Protein Function
RNF139 has several biochemical functions, for example, ligase activity,protease binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RNF139 itself. We selected most functions RNF139 had, and list some proteins which have the same functions with RNF139. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | CCNE2,IGSF21B,IGF2R,ABLIM1,FOXC2,ELK4,SPAG5,CAPN1,BRCC3,MAPKBP1 |
| receptor activity | NLGN4X,SLC40A1,KLRK1,IL18RAP,NLGN3A,TNPO3,GPA33,PVR,CLEC4E,CALCR |
| ubiquitin protein ligase activity | RNF2,RNF41,UBE2NB,UBR3,TOPORS,HERC3,UHRF1,RNF34,TRAF6,RBBP6 |
| ligase activity | UBE2G1B,UBR1,DTX1,PET112L,TRIM6,UBE4B,RCHY1,MARCH5,RNF34,RNF144B |
| ubiquitin-like protein transferase activity | ATG16L1,ARIH1,RNF14,ATG3,UBL4A |
| protease binding | F3,FLOT2,MBP,SERPINB4,CFLAR,UBC,DVL3,SERPINC1,TIMP1,VWF |
| ubiquitin-protein transferase activity | FLJ11011L,UBE2C,FBXL6,TRAF2,BRAP,ARIH1L,STUB1,RNF125,BIRC3,KLHL20 |
| zinc ion binding | ZNRF2B,FBXO30A,MPI,KDM5A,DTX3L,GATA1A,ZCCHC11,ZNFL1,NANOS2,ESR1 |
Interacting Protein
RNF139 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RNF139 here. Most of them are supplied by our site. Hope this information will be useful for your research of RNF139.
HM13;XBP1;VHL;UBE2H;UBE2U;UBE2Z
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References
- Wang, XW; Wei, W; et al. RING Finger Proteins Are Involved in the Progression of Barrett Esophagus to Esophageal Adenocarcinoma: A Preliminary Study. GUT AND LIVER 8:487-494(2014).
- Kato, T; Franconi, CP; et al. Analysis of the t(3;8) of hereditary renal cell carcinoma: a palindrome-mediated translocation. CANCER GENETICS 207:133-140(2014).
