RLIM
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Official Full Name
ring finger protein, LIM domain interacting -
Overview
The protein encoded by this gene is a RING-H2 zinc finger protein. It has been shown to be an E3 ubiquitin protein ligase that targets LIM domain binding 1 (LDB1/CLIM), and causes proteasome-dependent degradation of LDB1. This protein and LDB1 are co-repressors of LHX1/LIM-1, a homeodomain transcription factor. Multiple alternatively spliced variants, encoding the same protein, have been identified. -
Synonyms
RNF12;FLJ25923;FLJ41093;FLJ42887;FLJ45986;MGC15161;NY-REN-43;DKFZp686N06224;E3 ubiquitin-protein ligase RLIM;R-LIM;OTTHUMP00000023574;OTTHUMP00000023575;ring finger protein 12;E3 ubiquitin-protein ligase RNF12;renal carcinoma antigen NY-REN-43;RING finger LIM domain-binding protein;ring zinc finger protein NY-REN-43antigen;LIM domain-interacting RING finger protein;ring zinc finger LIM domain binding protein;RLIM;ring finger protein LIM domain interacting
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Chicken
- E.coli
- Mammalian Cell
- HEK293
- GST
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RLIM-2318H | Recombinant Human RLIM, GST-tagged | E.coli | Human | GST | 276-350aa | |
| RLIM-14254M | Recombinant Mouse RLIM Protein | Mammalian Cell | Mouse | His |
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| RLIM-3903R | Recombinant Rhesus monkey RLIM Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| RLIM-498H | Recombinant Human RLIM Protein, His-tagged | E.coli | Human | His |
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| RLIM-6391C | Recombinant Chicken RLIM | Mammalian Cell | Chicken | His |
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| RLIM-1517HCL | Recombinant Human RLIM cell lysate | Human | Non |
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| RLIM-3720R | Recombinant Rhesus Macaque RLIM Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| RLIM-3720R-B | Recombinant Rhesus Macaque RLIM Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| RLIM-7622M | Recombinant Mouse RLIM Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| RLIM-7622M-B | Recombinant Mouse RLIM Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
RLIM involved in several pathways and played different roles in them. We selected most pathways RLIM participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with RLIM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
RLIM has several biochemical functions, for example, ligase activity,transcription corepressor activity,ubiquitin protein ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RLIM itself. We selected most functions RLIM had, and list some proteins which have the same functions with RLIM. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin-protein transferase activity | PJA2,MARCH2,FBXW2,RNF6,NHLRC1,TRAF7,UBE2R2,WWP1,RNF11,CBLB |
| transcription corepressor activity | HDAC3,MECP2,HSF4,PPP1R13L,ZBTB32,SAP30,PIAS1,HSBP1,KCTD1,KCNIP3 |
| zinc ion binding | MARCH8,USP5,ACE,ZNRF2B,TK1,ZRANB2,ASH1L,SIRT5,PARP1,SLC25A46 |
| ubiquitin protein ligase activity | HECW1B,FBXL22,RNF144A,MARCH8,ITCH,PJA2,RNF6,NHLRC1,ARIH1,ANKIB1 |
| ligase activity | RNF13,HLTF,UBR1,MIB1,ACSM2,RNF168,RCHY1,MID1,SMURF2,MIB2 |
Interacting Protein
RLIM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RLIM here. Most of them are supplied by our site. Hope this information will be useful for your research of RLIM.
LDB2;UBE2O;UBE2D1;UBE2E1;UBE2D3;RPS14;UBE2D2;SNX17;LNX2;UBE2E2;UBE2D4;UBXN1;TOLLIP;LMO2;LDB1
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