RIT1
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Official Full Name
Ras-like without CAAX 1 -
Overview
This gene encodes a member of a subfamily of Ras-related GTPases. The encoded protein is involved in regulating p38;MAPK-dependent signaling cascades related to cellular stress. This protein also cooperates with nerve growth factor to;promote neuronal development and regeneration. Alternate splicing results in multiple transcript variants. -
Synonyms
RIT1;Ras-like without CAAX 1;Ric (Drosophila) like, expressed in many tissues , RIT;GTP-binding protein Rit1;GTP binding protein Roc1;MGC125864;MGC125865;RIBB;Ric like;expressed in many tissues;ROC1;GTP-binding protein Roc1;ras-like without CAAX protein 1;Ric-like, expressed in many tissues;ras-like protein expressed in many tissues;RIT
Recombinant Proteins
- Chicken
- Rhesus macaque
- Zebrafish
- Human
- Mouse
- Mammalian Cell
- HEK293
- HEK293T
- His
- Non
- His&Fc&Avi
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RIT1-2981C | Recombinant Chicken RIT1 | Mammalian Cell | Chicken | His |
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| RIT1-3901R | Recombinant Rhesus monkey RIT1 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| RIT1-7037Z | Recombinant Zebrafish RIT1 | Mammalian Cell | Zebrafish | His |
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| RIT1-2330HCL | Recombinant Human RIT1 293 Cell Lysate | HEK293 | Human | Non |
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| RIT1-3718R | Recombinant Rhesus Macaque RIT1 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| RIT1-3718R-B | Recombinant Rhesus Macaque RIT1 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| Rit1-5526M | Recombinant Mouse Rit1 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| RIT1-6153H | Recombinant Human RIT1 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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Involved Pathway
RIT1 involved in several pathways and played different roles in them. We selected most pathways RIT1 participated on our site, such as NGF signalling via TRKA from the plasma membrane,Neurotrophic factor-mediated Trk receptor signaling,Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with RIT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signalling to ERKs | KIDINS220B,RIT2 |
| Signal Transduction | ARAP1,AKR1C6,SHB,WIPF3,LGR5,DRAP1,ARHGEF25,RTKN,CRABP1,OXER1 |
| Signalling by NGF | PCSK6,DNAL4A,AATF,OMG,RTN4A,PCSK5,LINGO1,PRDM4,DNAL4,KIDINS220B |
| Trk receptor signaling mediated by the MAPK pathway | RIT2,RUSC1 |
| NGF signalling via TRKA from the plasma membrane | RIT2,DNAL4A,NTF7,DNAL4,ADCYAP1,DNAL4B,KIDINS220B |
| Signalling to p38 via RIT and RIN | RIT2 |
| Neurotrophic factor-mediated Trk receptor signaling | DYNLT1,RGS19,RIT2,MCF2L,GIPC1,FAIM |
Protein Function
RIT1 has several biochemical functions, for example, GTP binding,calmodulin binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RIT1 itself. We selected most functions RIT1 had, and list some proteins which have the same functions with RIT1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTP binding | RHOV,GNAL,GIMAP1,GNAV1,RAB40C,RRAD,HBS1L,RAB40AL,RABL6,ARL4A |
| calmodulin binding | PPP3CC,MARCKSL1,CAMK2D,KCNH1,TJP1,CNN3,KCNN1B,RYR3,VAMP2,MAP6 |
| protein binding | KLHL41,TRIAP1,UBL7,CRK,PTTG1,FAM212A,SIKE1,TBC1D5,VPS54,SLX4IP |
Interacting Protein
RIT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RIT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RIT1.
RLF;SRPK2;GRB2;RGL1;IFRD1;AP2A1;PTN;MLLT4;RALGDS;RIF1
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