RIPK1
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Official Full Name
receptor (TNFRSF)-interacting serine-threonine kinase 1 -
Overview
Receptor-interacting serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the RIPK1 gene. -
Synonyms
RIPK1;receptor (TNFRSF)-interacting serine-threonine kinase 1;receptor-interacting serine/threonine-protein kinase 1;RIP;RIP-1;cell death protein RIP;receptor interacting protein;receptor-interacting protein 1;serine/threonine-protein kinase RIP
Recombinant Proteins
- Human
- Rat
- Mouse
- Chicken
- Dog
- Monkey
- Insect Cells
- Sf9 Cells
- Wheat Germ
- E.coli
- HEK293
- Mammalian Cells
- Yeast
- Insect cells
- In Vitro Cell Free System
- GST
- His
- Non
- SUMO
- Myc
Involved Pathway
RIPK1 involved in several pathways and played different roles in them. We selected most pathways RIPK1 participated on our site, such as NF-kappa B signaling pathway,Apoptosis,Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RIPK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Apoptosis | CASP6,PRKAR2B,IL1RAP,CASP10,CASP3A,PIK3CG,CASP8,CAPN2B,BADB,ENDOG |
| Hepatitis C | ARAF,CLDN4,IFNA16,TNFRSF1A,CLDN3,PPP2CB,IFNA13,BRAF,STAT1,CLDN14 |
| TNF signaling pathway | MAGI2,MAP2K1,CCL2,MMP9,CXCL3,PGAM5,MAP3K14,MAPK9,TNFRSF1A,MAP3K7IP3 |
| Cytosolic DNA-sensing pathway | TREX1,IFNA13,POLR3A,CASPA,IFNA5,POLR2E,POLR3E,IFNA3,POLR3C,CASP1 |
| RIG-I-like receptor signaling pathway | IRF7,Ifna11,IFNA2,MAVS,TBK1,IFNB,FADD,IFNW1,MAP3K1,MAPK14B |
| NF-kappa B signaling pathway | SYK,Ccl21a,PIDD1,ICAM1,NFKB2,Ccl21c,PLCG2,BCL2A1,BCL2,LTA |
| Epstein-Barr virus infection | AKT1,AKAP8L,DDX58,POLR2G,PSMC3,FGR,HSPA6,POLR2B,IKBKG,MAPK8 |
| Toll-like receptor signaling pathway | TNF,LY96,IRF5,IFNA4,TLR8,CCL5,CXCL8B.3,NFKB1,PIK3CD,IFNA14 |
Protein Function
RIPK1 has several biochemical functions, for example, ATP binding,death domain binding,death receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RIPK1 itself. We selected most functions RIPK1 had, and list some proteins which have the same functions with RIPK1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin protein ligase binding | H2-AB1,HSPA8,RPA2,WASH1,UBE2G1A,RNF20,CASP10,TMEM189,LYN,BAG6 |
| protein serine/threonine kinase activity | PIM1,BCKDK,SQSTM1,PLK1,RAF1A,RPS6KA1,MYO3B,TSSK1,TSSK6,CDC7 |
| death domain binding | DAPL1,TRADD,CRADD,DAP1B,DAP |
| protein kinase activity | HIPK2,ROCK2A,PTK2AA,EPHA4B,ANKK1,PINK1,DCKL1B,IRAK4,MAP3K2,PRKD2 |
| ATP binding | TSSK4,MAP3K5,BMPR1A,MAPK4,ILK,PIK3C2A,MARK3,PLK4,UBA2,STK25 |
| protein complex binding | KAT2B,UGT1A6B,PAFAH1B1,TULP2,CPD,LAMB3,KCTD5,THRA,C8B,GNB1 |
| death receptor binding | Casp3,FADD,TNFSF15,NOL3,CFLAR,PRDM4,Fasl,BID,CASP8,MYD88 |
| identical protein binding | FBXW7,AGXT2L2,SMAD3,PSME3,FUS,TPRG1L,HAND1,SYP,CLDNG,IL12B |
| protein binding | MED11,MARVELD2,MPP2,RNF146,SHISA3,ANKS1A,TRIM43,PCOLCE,RPL5,FGF3 |
Interacting Protein
RIPK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RIPK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RIPK1.
CASP8
Resources
Research Area
Apoptosis Adaptor ProteinsRegulator of NFkB
Intracellular Kinases in the Akt Pathway
NOD-like Receptors and the Inflammasome
RIG-I-like Receptors
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References
