RGS6

  • Official Full Name

    regulator of G-protein signaling 6

  • Overview

    This gene encodes a member of the RGS (regulator of G protein signaling) family of proteins, which are defined by the presence of a RGS domain that confers the GTPase-activating activity of these proteins toward certain G alpha subunits. This protein also belongs to a subfamily of RGS proteins characterized by the presence of DEP and GGL domains, the latter a G beta 5-interacting domain. The RGS proteins negatively regulate G protein signaling, and may modulate neuronal, cardiovascular, lymphocytic activities, and cancer risk. Many alternatively spliced transcript variants encoding different isoforms with long or short N-terminal domains, complete or incomplete GGL domains, and distinct C-terminal domains, have been described for this gene, however, the full-length nature of some of these variants is not known.

  • Synonyms

    RGS6;regulator of G-protein signaling 6;regulator of G protein signalling 6;DKFZp313G1241;FLJ43552;G protein signaling 6 regulator;GAP;GTPase activating protein;MGC142132;Regulator of G protein signaling 6;RGS 6;S914;H_DJ1108A12.1;WUGSC:H_DJ0283M22.1;WUGSC:H_DJ1108A12.1;regulator of G-protein signalling 6

Recombinant Proteins

  • Mouse
  • Zebrafish
  • Rhesus macaque
  • Chicken
  • Rat
  • Human
  • Mammalian Cell
  • E.coli
  • HEK293
  • His
  • His&T7
  • Non
  • His&GST
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
RGS6-14147M Recombinant Mouse RGS6 Protein Mammalian Cell Mouse His
RGS6-3469Z Recombinant Zebrafish RGS6 Mammalian Cell Zebrafish His
RGS6-3877R Recombinant Rhesus monkey RGS6 Protein, His-tagged Mammalian Cell Rhesus macaque His
RGS6-4318C Recombinant Chicken RGS6 Mammalian Cell Chicken His
Rgs6-8188R Recombinant Rat Rgs6 protein, His & T7-tagged E.coli Rat His&T7 Met1~Ser472
RGS6-2370HCL Recombinant Human RGS6 293 Cell Lysate HEK293 Human Non
RGS6-2016H Recombinant Human RGS6 Protein, His&GST-tagged E.coli Human His&GST Met1-Glu127
RGS6-3694R Recombinant Rhesus Macaque RGS6 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
RGS6-3694R-B Recombinant Rhesus Macaque RGS6 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
RGS6-7570M Recombinant Mouse RGS6 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
RGS6-7570M-B Recombinant Mouse RGS6 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    RGS6 involved in several pathways and played different roles in them. We selected most pathways RGS6 participated on our site, such as Calcium Regulation in the Cardiac Cell,G alpha (i) signalling events,GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with RGS6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Signaling by GPCR GPR65,PENK,OPN4A,PYY,ACKR4,OR10A5,OXGR1A.3,RAMP3,RGS1,ARHGEF1B
    G alpha (i) signalling events GAL,FPR-RS4,RGS1,AMCF-II,ADRA2C,APPA,TAS2R7,SSTR1,RGR,TAS2R16
    Calcium Regulation in the Cardiac Cell PKIB,CX35.4,GJB3,GNB5B,RGS18,CX30.3,CASQ2,ADRB3,ADRA1D,GJA4
    GPCR downstream signaling ADM,LPAR5A,CALCRL,ARHGEF16,SSTR3,CCR6,CCR3,OPN1LW1,LPAR2A,CCR1
    Signal Transduction SST1.1,SH2B3,SHRPRBCK1R,RHOV,PMCH,FSTL1,USP34,PTPRU,CCL35.2,ABCA4A
    Myometrial Relaxation and Contraction Pathways RGS18,IGFBP2,ACTA1,PKIG,CRH,RGS20,IGFBP4,RAMP1,RGS10,CNN2

    Protein Function

    RGS6 has several biochemical functions, for example, GTPase activator activity,protein binding,signal transducer activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RGS6 itself. We selected most functions RGS6 had, and list some proteins which have the same functions with RGS6. You can find most of the proteins on our site.

    Function Related Protein
    GTPase activator activity SRGAP2B,CDC42EP3,ARHGAP19,RASAL2,RABEP2,ELMOD1,RGS5B,RALBP1,ARHGAP11A,RGS3
    protein binding GAS1,TESK1,BIN1,EPAS1,TUBB4A,CLOCK,AZIN2,MARCH2,RBM15,ABCG8
    signal transducer activity PLCB4,MADD,SH2B1,GNG3,OLFR470,APLNRA,OLFCS2,PTGER1A,ADRA2DB,PLK2

    Interacting Protein

    RGS6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RGS6 here. Most of them are supplied by our site. Hope this information will be useful for your research of RGS6.

    HSP90AB1;PSMD2;HSP90AB1;AARSD1

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