RGS18
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Official Full Name
regulator of G-protein signaling 18 -
Overview
This gene encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. -
Synonyms
RGS18;regulator of G-protein signaling 18;regulator of G protein signalling 18;RGS13;Regulator of G protein signalling 13;RGS 18;RGS18_HUMAN;regulator of G-protein signalling 13;regulator of G-protein signalling 18
Recombinant Proteins
- Human
- Chicken
- Zebrafish
- Rat
- E.coli
- Mammalian Cell
- HEK293
- GST
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RGS18-2277H | Recombinant Human RGS18, GST-tagged | E.coli | Human | GST | 1-235aa | |
| RGS18-4625C | Recombinant Chicken RGS18 | Mammalian Cell | Chicken | His |
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| RGS18-4673Z | Recombinant Zebrafish RGS18 | Mammalian Cell | Zebrafish | His |
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| RGS18-5016R | Recombinant Rat RGS18 Protein | Mammalian Cell | Rat | His |
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| RGS18-2381HCL | Recombinant Human RGS18 293 Cell Lysate | HEK293 | Human | Non |
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| RGS18-1183H | Recombinant Human RGS18 Protein, His-tagged | E.coli | Human | His |
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| RGS18-301373H | Recombinant Human RGS18 protein, GST-tagged | E.coli | Human | GST | Met1-Leu235 |
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| RGS18-4675R | Recombinant Rat RGS18 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| RGS18-4675R-B | Recombinant Rat RGS18 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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Involved Pathway
RGS18 involved in several pathways and played different roles in them. We selected most pathways RGS18 participated on our site, such as Calcium Regulation in the Cardiac Cell,G alpha (i) signalling events,G alpha (q) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with RGS18 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Calcium Regulation in the Cardiac Cell | CASQ1,RGS20,RGS14,ANXA6,RGS17,RGS11,RGS5,GNB3B,GJB3,ADRA1D |
| G alpha (q) signalling events | APPA,TAC1,GCGB,DGKG,NMUR1,TRPC7,TAE1,ABHD6B,UTS2,GPR65 |
| G alpha (i) signalling events | RGS11,INSL5,AGTR2,HCAR1-2,OPN5,AGT,NPB,SOUL4,GPR18,CCR3 |
| Signaling by GPCR | RAMP3,CRHB,KISS1,GPR37B,GPR31,ADM2A,PROK2,CXCR7B,VIP,EMR1 |
| Gastrin-CREB signalling pathway via PKC and MAPK | TRH,EDNRAB,KISS1,GPR68,LPAR2A,NMUR1,PROKR1A,TRIO,OPN4B,CCK |
| Myometrial Relaxation and Contraction Pathways | MAFF,RGS17,RGS5,IGFBP5,CNN2,CRCP,GUCA2A,RGS6,IGFBP2,RGS14 |
| GPCR downstream signaling | RXFP2,EDN3,OPN1LW1,NMBB,EDNRA,CCL27,LPAR2A,NMS,CGA,GNA13 |
| Signal Transduction | ANXA1C,CDC37,OXER1,RIT2,GPR132,OPN4.1,DISP2,SPOP,APOA4B.2,NRP2 |
Protein Function
RGS18 has several biochemical functions, for example, GTPase activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RGS18 itself. We selected most functions RGS18 had, and list some proteins which have the same functions with RGS18. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTPase activator activity | ASAP2,PTPLAD1,CHML,TBC1D17,RASA1,TBC1D22A,ECT2,RGS9B,ARHGAP12,ARHGAP9 |
Interacting Protein
RGS18 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RGS18 here. Most of them are supplied by our site. Hope this information will be useful for your research of RGS18.
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References
- Gegenbauer, K; Nagy, Z; et al. Cyclic Nucleotide Dependent Dephosphorylation of Regulator of G-Protein Signaling 18 in Human Platelets. PLOS ONE 8:-(2013).
- Doupnik, CA; Xu, T; et al. Profile of RGS expression in single rat atrial myocytes. BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION 1522:97-107(2001).
- Iwai, K; Koike, M; et al. RGS18 acts as a negative regulator of osteoclastogenesis by modulating the acid-sensing OGR1/NFAT signaling pathway. JOURNAL OF BONE AND MINERAL RESEARCH 22:1612-1620(2007).
