RGS13
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Official Full Name
regulator of G-protein signaling 13 -
Overview
The protein encoded by this gene is a member of the regulator of G protein signaling (RGS) family. RGS family members share similarity with S. cerevisiae SST2 and C. elegans egl-10 proteins, which contain a characteristic conserved RGS domain. RGS proteins accelerate GTPase activity of G protein alpha-subunits, thereby driving G protein into their inactive GDP-bound form, thus negatively regulating G protein signaling. RGS proteins have been implicated in the fine tuning of a variety of cellular events in response to G protein-coupled receptor activation. The biological function of this gene, however, is unknown. Two transcript variants encoding the same isoform exist. -
Synonyms
RGS13;regulator of G-protein signaling 13;regulator of G protein signalling 13;regulator of G-protein signalling 13;MGC17173
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RGS13-2275H | Recombinant Human RGS13, GST-tagged | E.coli | Human | GST | 1-159aa | |
| RGS13-5606Z | Recombinant Zebrafish RGS13 | Mammalian Cell | Zebrafish | His |
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| RGS13-688H | Recombinant Human RGS13 Protein, His-tagged | E.coli | Human | His |
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| RGS13-2384HCL | Recombinant Human RGS13 293 Cell Lysate | HEK293 | Human | Non |
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| Rgs13-5492M | Recombinant Mouse Rgs13 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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Involved Pathway
RGS13 involved in several pathways and played different roles in them. We selected most pathways RGS13 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with RGS13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
RGS13 has several biochemical functions, for example, GTPase activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RGS13 itself. We selected most functions RGS13 had, and list some proteins which have the same functions with RGS13. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTPase activator activity | ALDH1A2,ARHGAP24,TBC1D17,RGS6,ARHGAP4,CDC42EP3,RANBP1,TBC1D10A,NIPAL1,ARHGAP18 |
Interacting Protein
RGS13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RGS13 here. Most of them are supplied by our site. Hope this information will be useful for your research of RGS13.
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References
- Wang, JH; New, JS; et al. Extension of the Germinal Center Stage of B Cell Development Promotes Autoantibodies in BXD2 Mice. ARTHRITIS AND RHEUMATISM 65:2703-2712(2013).
- Pise-Masison, CA; Radonovich, M; et al. Gene expression profiling of ATL patients: compilation of disease-related genes and evidence for TCF4 involvement in BIRC5 gene expression and cell viability. BLOOD 113:4016-4026(2009).
