RFXAP
-
Official Full Name
regulatory factor X-associated protein -
Overview
Major histocompatibility (MHC) class II molecules are transmembrane proteins that have a central role in development and control of the immune system. The protein encoded by this gene, along with regulatory factor X-associated ankyrin-containing protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription. Once bound to the promoter, this complex associates with the non-DNA-binding factor MHC class II transactivator, which controls the cell type specificity and inducibility of MHC class II gene expression. Mutations in this gene have been linked to bare lymphocyte syndrome type II, complementation group D. Transcript variants utilizing different polyA signals have been found for this gene. -
Synonyms
RFXAP;regulatory factor X-associated protein;Regulatory factor X associated protein;RFX associated protein;RFX DNA binding complex 36 kDa subunit;RFX DNA-binding complex 36 kDa subunit;RFX-associated protein;RFXAP_HUMAN;OTTHUMP00000018260
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- E.coli
- Mammalian Cell
- HEK293
- GST
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RFXAP-2267H | Recombinant Human RFXAP, GST-tagged | E.coli | Human | GST | C-193aa | |
| RFXAP-2445H | Recombinant Human RFXAP protein, His-tagged | E.coli | Human | His | 80-272 aa | |
| RFXAP-14121M | Recombinant Mouse RFXAP Protein | Mammalian Cell | Mouse | His |
|
|
| RFXAP-3865R | Recombinant Rhesus monkey RFXAP Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
|
|
| RFXAP-1496HCL | Recombinant Human RFXAP cell lysate | Human | Non |
|
||
| RFXAP-3682R | Recombinant Rhesus Macaque RFXAP Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
|
|
| RFXAP-3682R-B | Recombinant Rhesus Macaque RFXAP Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
|
||
| RFXAP-7555M | Recombinant Mouse RFXAP Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
|
|
| RFXAP-7555M-B | Recombinant Mouse RFXAP Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
|
Involved Pathway
RFXAP involved in several pathways and played different roles in them. We selected most pathways RFXAP participated on our site, such as Antigen processing and presentation,Tuberculosis,Primary i, which may be useful for your reference. Also, other proteins which involved in the same pathway with RFXAP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Primary i | AICDA,TNFRSF13B,BTK,TAP1,ICOS,IKBKG,CD3D,AIRE,ORAI1,CD40LG |
| Antigen processing and presentation | KIR2DS3,HLA-DRB1,KIR2DL1,KIR3DL2,KIR2DS5,HLA-DRA,HSPA1A,CTSB,HLA-DMA,HSP90AB1 |
| Tuberculosis | Itgam&Itgb2,FADD,TGFB2,CAMP,SPHK1,ATP6V0C,BID,IRAK1,ATP6V0A2,CASP9 |
| nodeficiency | ORAI1,RAG1,DCLRE1C,CD4,IGLL1,ZAP70,BTK,RFXANK,BLNK,UNG |
Protein Function
RFXAP has several biochemical functions, for example, DNA binding,transcription coactivator activity,transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RFXAP itself. We selected most functions RFXAP had, and list some proteins which have the same functions with RFXAP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription coactivator activity | TAF7L,TAF1,Ankar,PSMC3,SUB1A,TRIM32,KLF7,TCF3,RAP2C,MMS19 |
| DNA binding | TOP2A,ZNF230,ISL2,ZBED2,ZNF70,RFX1A,NR1H3,ZFP579,TP63,POLDIP2 |
| transcription factor activity, sequence-specific DNA binding | NR6A1A,PHF5A,DMBX1,NFE2L1,POU3F2,SPI1B,FOXD1L,SLAMF7,RERE,NFE2L2A |
Interacting Protein
RFXAP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RFXAP here. Most of them are supplied by our site. Hope this information will be useful for your research of RFXAP.
EPS8;RFX5;Rfx5
Resources
Related Services
Related Products
References
