RFC4
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Official Full Name
replication factor C (activator 1) 4, 37kDa -
Overview
The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 37 kD subunit. This subunit forms a core complex with the 36 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding the same protein have been reported. -
Synonyms
RFC4;replication factor C (activator 1) 4, 37kDa;replication factor C (activator 1) 4 (37kD);replication factor C subunit 4;A1;A1 37 kDa subunit;activator 1 37 kDa subunit;RFC 37 kDa subunit;RFC37;RF-C 37 kDa subunit;activator 1 subunit 4;repli
Recombinant Proteins
- Zebrafish
- Mouse
- Chicken
- Rhesus macaque
- Human
- Mammalian Cell
- HEK293
- HEK293T
- E.coli
- His
- Non
- Myc&DDK
- His&T7
- GST
- His&Fc&Avi
Involved Pathway
RFC4 involved in several pathways and played different roles in them. We selected most pathways RFC4 participated on our site, such as DNA replication,Nucleotide excision repair,Mismatch repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with RFC4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Nucleotide Excision Repair | CUL4A,COPS7B,RAD23AB,YY1,INO80,RPA1,BIVM-ERCC5,POLD1,COPS2,RFC3 |
| DNA Replication | RFC1,POLD2,MCM6L,RNASEH1,MCM3,FEN1,MCM2,RPA1,GINS4,LIG1 |
| Mismatch repair | POLD2,POLD4,LIG1,POLD1,RFC1,MSH2,RPA4,RFC2,RFC5,RPA1 |
Protein Function
RFC4 has several biochemical functions, for example, ATP binding,contributes_to DNA clamp loader activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RFC4 itself. We selected most functions RFC4 had, and list some proteins which have the same functions with RFC4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | COPS4,TK1,KCNIP1,TUB,NPM3,CDC42EP1,NXF2,ATP6V1D,BCAM,TMPRSS7 |
| ATP binding | PRKAA2,CDK13,DTYMK,P2RX4,ABCB1,PKN1,ITM2C,BRIP1,TTK,MAP3K9 |
| contributes_to DNA clamp loader activity | RFC5,RFC2,DSCC1 |
Interacting Protein
RFC4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RFC4 here. Most of them are supplied by our site. Hope this information will be useful for your research of RFC4.
RFC5;RFC2;RNF41
Resources
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References
- Xiang, J; Fang, LK; et al. Levels of human replication factor C4, a clamp loader, correlate with tumor progression and predict the prognosis for colorectal cancer. JOURNAL OF TRANSLATIONAL MEDICINE 12:-(2014).
- Liu, D; Zhang, XX; et al. Sine oculis homeobox homolog 1 promotes DNA replication and cell proliferation in cervical cancer. INTERNATIONAL JOURNAL OF ONCOLOGY 45:1232-1240(2014).
