REST
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Official Full Name
RE1-silencing transcription factor -
Overview
This gene encodes a transcriptional repressor that represses neuronal genes in non-neuronal tissues. It is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regular of neurogenesis. Alternatively spliced transcript variants have been described [provided by RefSeq, Jul 2010] -
Synonyms
REST;RE1-silencing transcription factor;XBR;NRSF;repressor binding to the X2 box;neural-restrictive silencer factor;neuron restrictive silencer factor;RE1-silencing transcription factor variant E1a/E2/E4;RE1-silencing transcription factor variant E1a/E2/E3/E5;RE1-silencing transcription factor variant E1b/E2/E3/E5;RE1-silencing transcription factor variant E1c/E2/E3/E5;RE1-silencing transcription factor variant E1a/E2/E3/E4c;RE1-silencing transcription factor variant E1c/E2g/E3/E4;RE1-silencing transcription factor variant E1a/E2/E3/N3c/E4;RE1-silencing transcription factor variant E1b/E2/E3/N3c/E4;RE1-silencing transcription factor variant E1a/E2/E3/N3a/E4i;RE1-silencing transcription factor variant E1b/E2/E3/N3b/E4i;RE1-silencing transcription factor variant E1b/E2c/E2j/E3/E4;RE1-silencing transcription factor variant E1a/E2k/E2i/E3/E4j
Recombinant Proteins
- Mouse
- Rat
- Human
- Mammalian Cells
- HEK293
- E.coli
- His
- Non
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| REST-14084M | Recombinant Mouse REST Protein | Mammalian Cells | Mouse | His |
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| REST-5000R | Recombinant Rat REST Protein | Mammalian Cells | Rat | His |
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| REST-2417HCL | Recombinant Human REST 293 Cell Lysate | HEK293 | Human | Non |
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| REST-4659R | Recombinant Rat REST Protein, His (Fc)-Avi-tagged | HEK293 | Rat | Avi&Fc&His |
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| REST-4659R-B | Recombinant Rat REST Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| REST-6173H | Recombinant Human REST Protein (Glu748-Glu1097), N-His tagged | E.coli | Human | His | Glu748-Glu1097 |
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| REST-7530M | Recombinant Mouse REST Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| REST-7530M-B | Recombinant Mouse REST Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
REST involved in several pathways and played different roles in them. We selected most pathways REST participated on our site, such as Signaling pathways regulating pluripotency of stem cells,Huntingtons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with REST were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signaling pathways regulating pluripotency of stem cells | WNT1,FZD5,ISL1,FZD6,ACVR1B,MAPK11,PCGF3,WNT7A,JARID2,PIK3R2 |
| Huntingtons disease | NDUFS7,PLCB3,DNAL4,POLR2J3,NDUFA12,NDUFB10,TGM2,NDUFS4,COX4I2,PPARGC1A |
Protein Function
REST has several biochemical functions, for example, chromatin binding,core promoter binding,core promoter sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by REST itself. We selected most functions REST had, and list some proteins which have the same functions with REST. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| core promoter binding | IFI16,PYDC3,IFI203,MED1,XBP1,MYOD1,E2F3,AGO2,MTF1,NEUROG3 |
| metal ion binding | ZNF333,NRD1B,ZBTB41,USP4,ZNF222,BMX,GM12824,ZFP36L1B,SIRT7,SUV39H1A |
| transcription factor activity, sequence-specific DNA binding | UHRF1,E2F7,RARAB,CDX1A,ZFP2,PA2G4,TFCP2L1,TFDP1A,TBX3A,FOSL2 |
| transcription factor binding | TFDP2,WWP2,HMGB1,ID1,SMARCD3,GATA4,TMEM173,CTNNB1,MYBBP1A,SMAD2 |
| transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | KLF16,PPARA,SNAI2,TCF3,MYPOP,TGIF1,RCOR1,ZGPAT,HAND1,IFI203 |
| protein binding | NCKAP1,TMEM218,SIP1,BBS13,CBFB,PPP1R7,FYN,LAMP1,ZNF664-FAM101A,ODF1 |
| chromatin binding | CAMTA2,PBX2,PRKAA1,ATOH1A,JDP2,NKX6,RAG2,RUNX2,SHMT2,GLI2 |
| outward rectifier potassium channel activity | KCNK2,KCNQ1,KCNK5B,KCNA5,KCNB1,KCNK18,KCNK2B,KCNK1A |
| transcription regulatory region DNA binding | TFAP4,FOXA1,CEBPA,SALL1A,ERBB4,RFX3,OVOL2,SIX1,SALL3B,BCL11AB |
Interacting Protein
REST has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with REST here. Most of them are supplied by our site. Hope this information will be useful for your research of REST.
SMARCA4;SMARCC2;SMARCE1
Resources
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References
- Elbeshehy, EKF; Metwali, EMR; et al. Antiviral activity of Thuja orientalis extracts against watermelon mosaic virus (WMV) on Citrullus lanatus. SAUDI JOURNAL OF BIOLOGICAL SCIENCES 22:211-219(2015).
- Diaz-Torne, C; Perez-Herrero, N; et al. New medications in development for the treatment of hyperuricemia of gout. CURRENT OPINION IN RHEUMATOLOGY 27:164-169(2015).
