REL
-
Official Full Name
v-rel reticuloendotheliosis viral oncogene homolog -
Overview
NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls the transcription of DNA. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection (kappa light chains are critical components of immunoglobulins). Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory. -
Synonyms
REL;C-Rel;proto-oncogene c-Rel;OTTHUMP00000159786;OTTHUMP00000201246;C-Rel proto-oncogene protein;oncogene REL, avian reticuloendotheliosis;v-rel avian reticuloendotheliosis viral;oncogene homolog;NFkB, c-Rel subunit
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| REL-250Z | Recombinant Zebrafish REL | Mammalian Cells | Zebrafish | His |
|
|
| REL-4018C | Recombinant Chicken REL | Mammalian Cells | Chicken | His |
|
|
| REL-2424HCL | Recombinant Human REL 293 Cell Lysate | HEK293 | Human | Non |
|
|
| Rel-2013M | Recombinant Mouse Rel Protein, His-tagged | E.coli | Mouse | His | Phe93-Gly353 |
|
| REL-3421H | Recombinant Human REL protein, His-tagged | E.coli | Human | His | 3-616aa |
|
| REL-5508H | Recombinant Human REL protein, His-tagged | Yeast | Human | His | 3-616aa |
|
Involved Pathway
REL involved in several pathways and played different roles in them. We selected most pathways REL participated on our site, such as Ras signaling pathway,Transcriptional misregulation in cancer,Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with REL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Viral carcinogenesis | ACTN3,HDAC1,HIST1H4H,NRAS,HIST1H2BD,SND1,HIST1H2BM,PIK3R5,CCND2,RBPJL |
| Ras signaling pathway | ELK1,PLA2G12A,FGF6,PIK3CA,INS,PDGFB,MAPK3,MAPK1,FGFR2,CALM4 |
| Transcriptional misregulation in cancer | LMO2,ETV7,ARNT2,MPO,PTCRA,HIST3H3,GOLPH3,IGFBP3,HDAC2,PAX5 |
Protein Function
REL has several biochemical functions, for example, RNA polymerase II distal enhancer sequence-specific DNA binding,chromatin binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by REL itself. We selected most functions REL had, and list some proteins which have the same functions with REL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chromatin binding | CBX7,KAT2A,RERE,GLI2,JARID2,SMARCD1,NCAPD3,PCNA,CDC45,SKI |
| RNA polymerase II distal enhancer sequence-specific DNA binding | HNRNPC,BACH1,H2AFZ,NFKB1,HOXB5,GATA2,POU4F1,ATF2,ESRRB,CDX2 |
| protein binding | SKA3,TESK1,RRM1,HGD,NAT9,NINJ1,SERPINA3,HIST1H4K,RSPH1,SPATA8 |
| transcription factor activity, sequence-specific DNA binding | ZFP82,SOX32,VDRA,NFIX,ZNF606,POU1F1,BCL3,ZFP42,ZNF480,ZNF92 |
| transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding | SIX3,ZEB2,HCFC1,SIX6,CDX1,MIXL1,NFE2L1,SFPI1,FUBP1,PROP1 |
Interacting Protein
REL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with REL here. Most of them are supplied by our site. Hope this information will be useful for your research of REL.
TTC21A;NECAP1;a8k5h9_human;STRA13;b2r8y4_human;23500
Resources
Research Area
Apoptosis Transcription Factors and RegulatorsTranscription Factors in the Akt Pathway
NFkB
Natural Killer T (NKT) Cells
C-type Lectin Receptors
NOD-like Receptors and the Inflammasome
RIG-I-like Receptors
IL-17 Signaling Related Molecules
Oncoprotein-Transcription Factors
Related Services
Related Products
References
- Nichols, P; Li, L; et al. Rational design of viscosity reducing mutants of a monoclonal antibody: Hydrophobic versus electrostatic inter-molecular interactions. MABS 7:212-230(2015).
- Heise, N; De Silva, NS; et al. Germinal center B cell maintenance and differentiation are controlled by distinct NF-kappa B transcription factor subunits. JOURNAL OF EXPERIMENTAL MEDICINE 211:2103-2118(2014).
