RBM8A
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Official Full Name
RNA binding motif protein 8A -
Overview
Y14 (RNA binding motif protein 8A or RBM8A), an RNA-binding protein, contains a conserved RNA-binding motif. Y14 is found predominantly in the nucleus, although it is also present in the cytoplasm. It is preferentially associated with mRNAs produced by splicing, including both nuclear mRNAs and newly exported cytoplasmic mRNAs. It is thought that the protein remains associated with spliced mRNAs as a tag to indicate where introns had been present, thus coupling pre-and post-mRNA splicing events. Previously, it was thought that two genes encode this protein, RBM8A and RBM8B; it is now thought that the RBM8B locus is a pseudogene. Two alternative start codons result in two forms of the protein, and this gene also uses multiple polyadenylation sites. -
Synonyms
RBM8A;RNA binding motif protein 8A;RBM8;RNA-binding protein 8A;BOV 1A;BOV 1B;BOV 1C;RBM8B;Y14;ZNRP;BOV-1;binder of OVCA1-1;ribonucleoprotein RBM8;RNA-binding protein Y14;ribonucleoprotein RBM8A;RNA binding motif protein 8B;RNA-binding motif protein 8A;TAR;ZRNP1;BOV-1A;BOV-1B;BOV-1C;MDS014;DEL1q21.1;C1DELq21.1
Recombinant Proteins
- Mouse
- Zebrafish
- Human
- Rat
- Mammalian Cell
- E.coli
- HEK293
- HEK293T
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
RBM8A involved in several pathways and played different roles in them. We selected most pathways RBM8A participated on our site, such as RNA transport,mRNA surveillance pathway,Spliceosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with RBM8A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Spliceosome | TTC6,SF3B14,BCAS2,U2AF2,USP39,SF3B2,TRA2A,CDC5L,SNRPB,PRPF6 |
| RNA transport | BAT1,UPF3A,SMN2,EIF2B5,EEF1A1L2,EIF2B3,EIF4EA,EIF4G2B,EIF3G,NUP107 |
| mRNA surveillance pathway | PPP2R1B,ETF1B,PABPC1L2A,NXF3,NXT2,DAZAP1,PNN,CPSF1,MAGOH2,MAGOHB |
Protein Function
RBM8A has several biochemical functions, for example, RNA binding,mRNA binding,nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RBM8A itself. We selected most functions RBM8A had, and list some proteins which have the same functions with RBM8A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| nucleotide binding | EPHA2A,RASL11A,MYHZ1.2,CAMK1DB,RABL6,SRSF2A,GATB,POLD1,ARF1L,SRSF7A |
| protein binding | STK10,FXYD6,CYS1,NUDT14,KHDC1A,SS18,MLH3,ATF1,TSPAN1,MORN2 |
| RNA binding | FMR1,KHDC1,DDX3Y,NOL4,EIF4H,ETF1,CPSF3,TARDBP,RCL1,CSTF3 |
| poly(A) RNA binding | DIAP1,TFAM,SMNDC1,JUN,RPL13,CPEB3,DYNC1LI1,NME1,MTO1,FASTKD3 |
| mRNA binding | PTBP2,RBFOX2,LUC7L2,MRPL13,NXF2,QKI,FMR1,RBM38,CALR,NUDT16 |
Interacting Protein
RBM8A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RBM8A here. Most of them are supplied by our site. Hope this information will be useful for your research of RBM8A.
MAGOH
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References
- Nakamura, Y; Ishigaki, Y; et al. Immunostaining and time-lapse analysis of vinblastine-induced paracrystal formation in human A549 cells. ONCOLOGY LETTERS 8:2387-2392(2014).
