RBM5
-
Official Full Name
RNA binding motif protein 5 -
Overview
This gene is a candidate tumor suppressor gene which encodes a nuclear RNA binding protein that is a component of the spliceosome A complex. The encoded protein plays a role in the induction of cell cycle arrest and apoptosis through pre-mRNA splicing of multiple target genes including the tumor suppressor protein p53. This gene is located within the tumor suppressor region 3p21.3, and may play a role in the inhibition of tumor transformation and progression of several malignancies including lung cancer. -
Synonyms
RBM5;RNA binding motif protein 5;RNA-binding protein 5;H37;LUCA15;putative tumor suppressor LUCA15;renal carcinoma antigen NY-REN-9;G15;RMB5;FLJ39876
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rhesus macaque
- Rat
- Zebrafish
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- Human Cell
- GST
- His
- Non
- Myc&DDK
- Flag
- His&Fc&Avi
Involved Pathway
RBM5 involved in several pathways and played different roles in them. We selected most pathways RBM5 participated on our site, such as Gene Expression,Processing of Capped Intron-Containing Pre-mRNA,mRNA Splicing, which may be useful for your reference. Also, other proteins which involved in the same pathway with RBM5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| mRNA Splicing - Major Pathway | YBX1,HNRNPA0L,HNRNPR,SFRS3A,CCAR1,HNRNPD,HNRPL,HNRNPL,SF3B4,HNRNPF |
| mRNA Splicing | HNRNPA0L,YBX1,DNAJC8,PTBP1A,ZMAT5,BCAS2,SF3A3,HNRNPH1L,HNRNPA0,SF3B4 |
| Processing of Capped Intron-Containing Pre-mRNA | METTL3,PTBP1A,HNRNPR,WTAP,ZMAT5,THOC4,YBX1,RNPC3,PRPF8,CCAR1 |
| mRNA processing | CELF2,SFRS3A,ZFP740,SNRPN,RNASET2B,PTBP1,ADAM5,SUGP1,D19BWG1357E,EBI3 |
| Gene Expression | ZFP143,HNRNPL2,TP53RK,MED13A,NR2E3,ZNF143A,EIF1AX,ESR2B,NR2E1,TPRKB |
Protein Function
RBM5 has several biochemical functions, for example, DNA binding,RNA binding,mRNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RBM5 itself. We selected most functions RBM5 had, and list some proteins which have the same functions with RBM5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA binding | CTU1,PSMA6,KHDRBS1B,RBMX,BRCA1,SYNCRIP,IMPDH2,METTL14,IGF2BP3,MRPL3 |
| protein binding | CRABP2,MPLKIP,SBDS,MRPL13,RBFOX1,PLEKHB1,CASKIN1,TFF1,PNMA5,PARN |
| DNA binding | TBX3A,UBP1,ISX,ZFP37,SMAD9,LHFP,TLX2,ZNF823,NUPR1,HIC2 |
| mRNA binding | CPSF6,ZFP36,DHFR,MECP2,SSB,RC3H2,RBFOX3,DCP1B,EDC3,RPL7 |
| zinc ion binding | MAN2A2,DTNBA,ADH1A,QPCT,MMP23B,VPS29,TRIM68,BHMT2,TRIM35-28,ZKSCAN5 |
| poly(A) RNA binding | MEPCE,FXR2,STIP1,C3orf26,CELF1,RPL5,MRPL1,GNB2L1,ZFP36L1,PUF60 |
| nucleotide binding | ABCC5,RBM23,BSK146,RBMX,RBM10,RBM4.3,RPS24,GSK3AA,ATAD1A,ABCA6 |
Interacting Protein
RBM5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RBM5 here. Most of them are supplied by our site. Hope this information will be useful for your research of RBM5.
DHX15;PRPF19
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