RBBP7
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Official Full Name
retinoblastoma binding protein 7 -
Overview
This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010] -
Synonyms
RBBP7;retinoblastoma binding protein 7;RbAp46;histone-binding protein RBBP7;RBBP-7;retinoblastoma-binding protein 7;retinoblastoma-binding protein p46;retinoblastoma-binding protein RbAp46;histone acetyltransferase type B subunit 2;nucleosome-remodeling factor subunit RBAP46;G1/S transition control protein-binding protein RbAp46
Recombinant Proteins
- Mouse
- Human
- Rhesus macaque
- Rat
- Chicken
- Cynomolgus
- Mammalian Cell
- Wheat Germ
- HEK293
- E.coli
- Mammalian cells
- In Vitro Cell Free System
- HEK293T
- His
- Non
- His&SUMO
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
RBBP7 involved in several pathways and played different roles in them. We selected most pathways RBBP7 participated on our site, such as Cell Cycle,Cellular Senescence,Cellular responses to stress, which may be useful for your reference. Also, other proteins which involved in the same pathway with RBBP7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cellular Senescence | POT1,AGO1,POT1A,EED,CBX6A,TERF2,AGO3,HTATIP,TERF2IP,EHMT2 |
| Cellular responses to stress | CEBPB,RNF2,ST13,POT1A,CBX4,GABARAP,WIPI2,ASF1A,DPF1,NUPL2 |
| Cell cycle | PDS5B,NDE1,MYCB,PLK4,PCNA,RBBP8,NINL,NCAPH2,ANAPC11,SSNA1 |
| EGFR1 Signaling Pathway | AP2A1,WNK1,CEBPB,APPL2,RBB4L,ARF4,KLF11,GRB7,RALBP1,GRB10 |
| Deposition of new CENPA-containing nucleosomes at the centromere | CENPK,ITGB3BP,SMARCA5,HJURP,CENPO,NPM1,CENPA,MIS18BP1,MLF1IP,CENPN |
| Chromatin modifying enzymes | KDM5BA,KANSL3,SETD3,JHDM1D,ING4,MBIP,C3orf75,SAP18,KDM5B,ZZZ3 |
| Chromatin organization | SETD3,ARID1A,KDM2B,PADI3,SMARCB1B,CSRP2BP,MORF4L2,BRD1,CARM1,MTA2 |
| Chromosome Maintenance | OIP5,CENPQ,TINF2,SMARCA5,POLD3,POT1A,CENPC1,RUVBL2,CENPK,ITGB3BP |
Protein Function
RBBP7 has several biochemical functions, for example, RNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RBBP7 itself. We selected most functions RBBP7 had, and list some proteins which have the same functions with RBBP7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | SPRY4,FAM59A,C1QTNF1,SPOPL,OAZ3,TLR2,TUBGCP3,EIF2B2,SHPRH,ASF1B |
| RNA binding | IREB2,BRCA1,RPL7A,RCAN3,RNASEL2,EIF3K,RPL8,RBM39A,HNRNPL2,RPL28 |
Interacting Protein
RBBP7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RBBP7 here. Most of them are supplied by our site. Hope this information will be useful for your research of RBBP7.
HDAC1;DHX30;CDK2AP1;Mta2;NR2E3;HIST2H4B
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References
- Tetu, B; Popa, I; et al. Immunohistochemical analysis of possible chemoresistance markers identified by micro-arrays on serous ovarian carcinomas. MODERN PATHOLOGY 21:1002-1010(2008).
