RANBP1
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Official Full Name
RAN binding protein 1 -
Overview
Ran/TC4-binding protein, RanBP1, interacts specifically with GTP-charged RAN. RANBP1 encodes a 23-kD protein that binds to RAN complexed with GTP but not GDP. RANBP1 does not activate GTPase activity of RAN but does markedly increase GTP hydrolysis by the RanGTPase-activating protein (RanGAP1). The RANBP1 cDNA encodes a 201-amino acid protein that is 92% similar to its mouse homolog. In both mammalian cells and in yeast, RANBP1 acts as a negative regulator of RCC1 by inhibiting RCC1-stimulated guanine nucleotide release from RAN. -
Synonyms
RANBP1;RAN binding protein 1;ran-specific GTPase-activating protein;HTF9A;Ran specific GTPase activating protein;Ran-binding protein 1;RANG_HUMAN;OTTHUMP00000197515;OTTHUMP00000197594;OTTHUMP00000198444;OTTHUMP00000209649
Recombinant Proteins
- Xenopus laevis
- Zebrafish
- Chicken
- Mouse
- Human
- Rhesus macaque
- Mammalian Cell
- Wheat Germ
- HEK293
- E.coli
- In Vitro Cell Free System
- HEK293T
- His
- Non
- GST
- His&Fc&Avi
- Myc&DDK
Involved Pathway
RANBP1 involved in several pathways and played different roles in them. We selected most pathways RANBP1 participated on our site, such as HTLV-I infection,Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with RANBP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| HTLV-I infection | H2-AA,GSK3B,APC2,TNFRSF1A,CANX,VDAC3,PRKACG,PPP3CB,CD3E; CD3D,PIK3CA |
| Viral carcinogenesis | HIST1H4K,HIST1H2BG,CCNE1,PRKACG,PIK3R2,CCND2,TRP53,HIST2H2BB,EIF2AK2,STAT5B |
Protein Function
RANBP1 has several biochemical functions, for example, GDP-dissociation inhibitor activity,GTPase activator activity,Ran GTPase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RANBP1 itself. We selected most functions RANBP1 had, and list some proteins which have the same functions with RANBP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| Ran GTPase binding | BIRC5,XPO4,IPO7,IPO4,XPO6,KPNB1,IPO9,RANBP3,RANGAP1,TNPO1 |
| GTPase activator activity | AGFG2,SIPA1L2,EVI5L,RALGAPA2,AGAP2,JUN,RASGRP3,RGS3,SRGAP2,FAM13B |
| GDP-dissociation inhibitor activity | SH3BP4A,GPSM2L,RGS14,SH3BP4,ITGB1BP1,GDI1,GPSM1,GPSM1B |
Interacting Protein
RANBP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RANBP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RANBP1.
RAN;38505205;EIF1B;GH1;EPB41;TIMP2;MCC;MPG;HLA-B;VHL;IKBKE;Ranbp2;TNFRSF10D;FTSJ1;TNIK;TRAF6;acoA;1-phosphatidyl-1d-myo-inositol 3,4,5-trisphosphate
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References
- Hutten, S; Flotho, A; et al. The Nup358-RanGAP complex is required for efficient importin alpha/beta-dependent nuclear import. MOLECULAR BIOLOGY OF THE CELL 19:2300-2310(2008).
- Zhang, CM; Clarke, PR; et al. Roles of Ran-GTP and Ran-GDP in precursor vesicle recruitment and fusion during nuclear envelope assembly in a human cell-free system. CURRENT BIOLOGY 11:208-212(2001).
