RAET1E
-
Official Full Name
retinoic acid early transcript 1E -
Overview
This gene belong to the RAET1 family, which consists of major histocompatibility complex (MHC) class I-related genes located in a cluster on chromosome 6q24.2-q25.3. This and RAET1G protein differ from other RAET1 proteins in that they have type I membrane-spanning sequences at their C termini rather than glycosylphosphatidylinositol anchor sequences. This protein functions as a ligand for NKG2D receptor, which is expressed on the surface of several types of immune cells, and is involved in innate and adaptive immune responses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
RAET1E;retinoic acid early transcript 1E;NKG2D ligand 4;bA350J20.7;LETAL;ULBP4;Lymphocyte effector toxicity activation ligand;MGC125308;MGC125309;N2DL-4;N2DL4;NKG2D ligand 4 precursor;NKG2DL4;RAE-1-like transcript 4;RAET1E2;RL-4;OTTHUMP00000017403;OTTHUMP00000017404;OTTHUMP00000229731
Recombinant Proteins
- Human
- E.coli
- C-hFc
- HEK293
- Insect Cells
- His
- Fc
- Non
- His&Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RAET1E-2937H | Recombinant Human RAET1E protein, His-tagged | E.coli | Human | His | ||
| RAET1E-1387H |
Recombinant Human RAET1E protein, hFc-tagged
|
C-hFc | Human | His31-Asp225 |
|
|
| RAET1E-381H | Recombinant Human retinoic acid early transcript 1E, His-tagged | E.coli | Human | His | 31-225 a.a. |
|
| RAET1E-764H | Recombinant Human RAET1E Protein, Fc-tagged | HEK293 | Human | Fc | 1-225 a.a. |
|
| RAET1E-765H | Recombinant Human RAET1E Protein, His-tagged | HEK293 | Human | His | 1-225 a.a. |
|
| RAET1E-2549HCL | Recombinant Human RAET1E 293 Cell Lysate | HEK293 | Human | Non |
|
|
| RAET1E-206H | Recombinant Human RAET1E Protein, His-tagged | Insect Cells | Human | His | 31-225aa |
|
| RAET1E-209H | Recombinant Human RAET1E Protein, hIgG-His-tagged | Insect Cells | Human | His&Fc | 31-225aa |
|
Involved Pathway
RAET1E involved in several pathways and played different roles in them. We selected most pathways RAET1E participated on our site, such as Adaptive Immune System,Immune System,Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAET1E were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adaptive Immune System | SPSB4,AMICA1,AGO3,FGF20A,LILRB2,NRG4,FBXO44,CTSD,TRIM41,SIGLEC12 |
| Natural killer cell mediated cytotoxicity | HRAS,Raet1a,MAPK1,H60a,IFNB1,GM-CSF,IFNA21,CD244,PPP3CA,VAV2 |
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | GM11711,LAIR1,AF251705,CD300LB,SH2D1B,CD300C,CD160,TREM1,CD300A,CLEC2H |
| Immune System | DCTN6,CMTM2A,GZMM,TRIM38,IGHM,KLHL20,AP1B1,TRIM2,DUSP3,LGALS3 |
Protein Function
RAET1E has several biochemical functions, for example, natural killer cell lectin-like receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RAET1E itself. We selected most functions RAET1E had, and list some proteins which have the same functions with RAET1E. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| natural killer cell lectin-like receptor binding | HLA-E,CLEC2H,ULBP1,MICB,MICA,ULBP2,H60a,Raet1a,ULBP3,Mill2 |
Interacting Protein
RAET1E has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAET1E here. Most of them are supplied by our site. Hope this information will be useful for your research of RAET1E.
Resources
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References
- Cho, H; Chung, JY; et al. MICA/B and ULBP1 NKG2D ligands are independent predictors of good prognosis in cervical cancer. BMC CANCER 14:-(2014).
- Cox, ST; Laza-Briviesca, R; et al. Further polymorphism of the RAET1E/ULBP4 gene in humans. TISSUE ANTIGENS 84:435-437(2014).
