RAE1
-
Official Full Name
RAE1 RNA export 1 homolog (S. pombe) -
Overview
Mutations in the Schizosaccharomyces pombe Rae1 and Saccharomyces cerevisiae Gle2 genes have been shown to result in accumulation of poly(A)-containing mRNA in the nucleus, suggesting that the encoded proteins are involved in RNA export. The protein encoded by this gene is a homolog of yeast Rae1. It contains four WD40 motifs, and has been shown to localize to distinct foci in the nucleoplasm, to the nuclear rim, and to meshwork-like structures throughout the cytoplasm. This gene is thought to be involved in nucleocytoplasmic transport, and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Alternatively spliced transcript variants encoding the same protein have been found for this gene. -
Synonyms
RAE1;RAE1 RNA export 1 homolog (S. pombe);mRNA export factor;rae1 protein homolog;mRNA-associated protein mrnp 41;41;MNRP;MNRP41;D2Ertd342e;3230401I12Rik
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Rat
- Cynomolgus
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- His
- Non
- Myc&DDK
- GST
- His&Fc&Avi
Involved Pathway
RAE1 involved in several pathways and played different roles in them. We selected most pathways RAE1 participated on our site, such as RNA transport,Influenza A, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAE1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Influenza A | PIK3CG,MAP2K6,IFNA8,IFNA14,VDAC1,TNF,IL1A,ADAR,IFNA21,IL-8 |
| RNA transport | EIF4BA,NUP155,EIF4G2,NMD3,SMN2,EIF2S3Y,NXF1,RANBP2,EIF3H,EIF4G2B |
Protein Function
RAE1 has several biochemical functions, for example, RNA binding,microtubule binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RAE1 itself. We selected most functions RAE1 had, and list some proteins which have the same functions with RAE1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA binding | MIF4GDA,RBM48,SNRPA,RPF1,NSUN3,RPS3A,MRPL3,ELAVL4,Aff2,RPL34 |
| microtubule binding | DPYSL5,RGS14,MAPT,FMR1,KATNB1,CKAP5,KIF1B,CENPE,SPAG8,MTAP1B |
Interacting Protein
RAE1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAE1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RAE1.
Nup214;NXF1;SFN;USP11;Nup188;USP7;HNRNPUL1;DDX24;EEF2K;PTBP3;FN1;M;NSS;ERBB3;YAP1;NUP153;NUP107;GABARAPL2
Resources
Related Services
Related Products
References
- Huang, M; Sun, R; et al. Simultaneous knockdown of multiple ligands of innate receptor NKG2D prevents natural killer cell-mediated fulminant hepatitis in mice. HEPATOLOGY 57:277-288(2013).
- Deb, C; Howe, CL; et al. NKG2D contributes to efficient clearance of picornavirus from the acutely infected murine brain. JOURNAL OF NEUROVIROLOGY 14:261-266(2008).
