RAD51B
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Official Full Name
RAD51 paralog B -
Overview
The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts with the other family members, such as RAD51, XRCC2, and XRCC3. Overexpression of this gene was found to cause cell cycle G1 delay and cell apoptosis, which suggested a role of this protein in sensing DNA damage. At least three alternatively spliced transcript variants encoding distinct isoforms have been observed. Rearrangements between this locus and high mobility group AT-hook 2 (HMGA2, GeneID 8091) have been observed in uterine leiomyomata. [provided by RefSeq, Jul 2011] -
Synonyms
RAD51B;RAD51 paralog B;REC2;R51H2;RAD51L1;DNA repair protein RAD51 homolog 2;RAD51 homolog B;RecA-like protein;recombination repair protein
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RAD51L1-2157H | Recombinant Human RAD51L1 protein, His-tagged | E.coli | Human | His | 1-384aa | |
| RAD51B-121H | Recombinant Human RAD51B protein, T7/His-tagged | E.coli | Human | His&T7 | 383 a.a. |
|
| RAD51B-12585Z | Recombinant Zebrafish RAD51B | Mammalian Cell | Zebrafish | His |
|
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| RAD51B-2465H | Recombinant human RAD51B, His-tagged | E.coli | Human | His | 1-350 a.a. |
|
| RAD51B-2554HCL | Recombinant Human RAD51L1 293 Cell Lysate | HEK293 | Human | Non |
|
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| Rad51b-6781M | Recombinant Mouse Rad51b Protein (Met121-Pro350), N-His tagged | E.coli | Mouse | His | Met121-Pro350 |
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Involved Pathway
RAD51B involved in several pathways and played different roles in them. We selected most pathways RAD51B participated on our site, such as Homologous recombination, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAD51B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Homologous recombination | POLD2,POLD1,EME1,RPA4,MUS81,RAD51D,RAD51L3,SYCP3,BRCA2,RAD51L1 |
Protein Function
RAD51B has several biochemical functions, for example, ATP binding,DNA binding,DNA-dependent ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RAD51B itself. We selected most functions RAD51B had, and list some proteins which have the same functions with RAD51B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to endodeoxyribonuclease activity | RAD51D,RAD51L3,XRCC2,DMC1,RAD51,ERCC4,RAD51L1 |
| double-stranded DNA binding | TP63,MRE11A,RAD51C,MTERF,TDP1,GATA1A,RBMS1,USF1,XRCC2,SATB1 |
| single-stranded DNA binding | SSBP3B,HNRNPDL,HNRNPA1,TDP1,HMGB1,CTC1,RAD51L3,ERCC4,RAD51C,TREX1 |
| ATP binding | SMCHD1,PIK3CD,CCT3,SGK2B,ABCC1,PAPSS1,EIF2AK3,MUSK,SMARCA4,SPHK2 |
| DNA-dependent ATPase activity | TTF2,RAD51L3,CHD6,SMARCA4,RAD51C,MSH5,RAD51D,SMARCAL1,DMC1,MSH2 |
| DNA binding | ESRRGB,SP140,MAP3K7,INSM2,ZFP319,ZNF469,HIST2H2AC,DDIT3,HOXA5A,PHTF2 |
| contributes_to four-way junction DNA binding | MSH6,RAD51C,XRCC2,RAD51L3,RAD51L1,XRCC3,MSH2,RAD51D |
| protein binding | PCBD1,GTF2E1,SULT1A2,KCNE3,TTC23L,SLU7,NKD2,PIWIL1,ABTB1,CKM |
| recombinase activity | RAD51C,RAD51L3,RBPJ,XRCC3,DMC1,RAD51D,XRCC2,RAD51L1,RAD51 |
Interacting Protein
RAD51B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAD51B here. Most of them are supplied by our site. Hope this information will be useful for your research of RAD51B.
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References
- Kim, K; Bang, SY; et al. High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci. ANNALS OF THE RHEUMATIC DISEASES 74:-(2015).
- McAllister, K; Yarwood, A; et al. Identification of BACH2 and RAD51B as Rheumatoid Arthritis Susceptibility Loci in a Meta-Analysis of Genome-Wide Data. ARTHRITIS AND RHEUMATISM 65:3058-3062(2013).
