RAD50
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Official Full Name
RAD50 homolog -
Overview
The DNA repair protein Rad50 is a member of the structural maintenance of chromosomes family (SMC) and plays an important role in cell cycle checkpoint signaling and double-strand break repair in response to DNA damage. Rad50 forms a complex with Mre11 an -
Synonyms
RAD50;RAD50 homolog (S. cerevisiae);RAD50 (S. cerevisiae) homolog;DNA repair protein RAD50;hRad50;RAD50 2;NBSLD;RAD502
Recombinant Proteins
- Rat
- Human
- Mouse
- Mammalian Cell
- HEK293
- E.coli
- His
- Non
- His&T7
- GST
- His&Fc&Avi
- N-His&C-Myc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RAD50-4910R | Recombinant Rat RAD50 Protein | Mammalian Cell | Rat | His |
|
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| RAD50-2557HCL | Recombinant Human RAD50 293 Cell Lysate | HEK293 | Human | Non |
|
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| RAD50-1744H | Recombinant Human RAD50 protein, His-tagged | E.coli | Human | His | Val400~Ala595 |
|
| Rad50-1746M | Recombinant Mouse Rad50 protein, His & T7-tagged | E.coli | Mouse | His&T7 | Met1~Leu234 |
|
| RAD50-301476H | Recombinant Human RAD50 protein, GST-tagged | E.coli | Human | GST | Leu275-Lys425 |
|
| RAD50-4569R | Recombinant Rat RAD50 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| RAD50-4569R-B | Recombinant Rat RAD50 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| RAD50-5353H | Recombinant Human RAD50 protein, His&Myc-tagged | E.coli | Human | N-His&C-Myc | 1-235aa |
|
| RAD50-5516H | Recombinant Human RAD50 Protein (Thr437-Val792), N-His tagged | E.coli | Human | His | Thr437-Val792 |
|
Involved Pathway
RAD50 involved in several pathways and played different roles in them. We selected most pathways RAD50 participated on our site, such as BARD1 signaling events,Cell Cycle,Cell Cycle Checkpoints, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAD50 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell cycle | SMAD3B,NUMA1,DCTN1,RAD21B,FAM175A,MYCB,NUF2,SDCCAG8,ZBTB17,CDK4 |
| DNA Double-Strand Break Repair | RNF4,TDP2,RHNO1,RAD17,HUS1,EME1,CLSPN,PPP4CB,WRN,TDP1 |
| Cellular responses to stress | UBN1,C11orf73,KIAA1967,GABARAP,EGLN2,PHC1,IGFBP7,MOV10,HIST1H1C,NUP35 |
| Cell Cycle Checkpoints | HIST3H2BB,BRE,BARD1,RAD9B,HUS1,MCM10,CHEK1,HIST4H4,HTATIP,CLSPN |
| DNA Damage/Telomere Stress Induced Senescence | TINF2,HIST1H1E,POT1A,ACD,TERF2,HIRA,H1F0,TERF2IP,HIST1H1C,CABIN1 |
| DNA Double Strand Break Response | SMARCA5,BABAM1,THRSP,TP53BP1,RNF168,UIMC1,EYA4,BARD1,KDM4B,BAZ1B |
| BARD1 signaling events | RBBP8,NPM1,CDK2,CSTF1,BARD1 |
| Cellular Senescence | HMGA1,CDKN2D,E2F2,BMI1B,KDM6B,HIRA,HMGA1-RS1,TERF2IP,ASF1A,PHC2 |
Protein Function
RAD50 has several biochemical functions, for example, contributes_to 3-5 exonuclease activity,ATP binding,contributes_to ATP-dependent DNA helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RAD50 itself. We selected most functions RAD50 had, and list some proteins which have the same functions with RAD50. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding, bridging | FGB,IVL,DDX20,COL8A2,CRADD,BFAR,TRIM5,TRIM17,MMS19,PPP4R2 |
| metal ion binding | ZFY2,FOLH1,ZKSCAN14,CHSY1,SLC25A25A,ZIK1,TGFBR2,CHORDC1B,ZIC2,VDRA |
| protein binding | RNF170,PELI1,COL10A1,TSPAN15,DRAM1,SCO1,POLR3GL,Reln,EPHB1,PNRC2 |
| ATP binding | CCT7,GSK3AB,ACTR2A,TSSK1,KIAA1804,DDX55,DDX42,CLCN3,ABCF2,KATNAL1 |
| DNA binding | IRX7,RB1,ZNF358,POLR3A,H2AFJ,NKX2.5,ZKSCAN17,ZNF726,PGR,FOXC1B |
| contributes_to ATP-dependent DNA helicase activity | MRE11A,MCM4,MCM6,MCM7,NBN |
| contributes_to single-stranded DNA endodeoxyribonuclease activity | ERCC1 |
Interacting Protein
RAD50 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAD50 here. Most of them are supplied by our site. Hope this information will be useful for your research of RAD50.
NBN;MDC1;FANCD2;ATRX
Resources
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References
- Huang, S; Peet, CR; et al. Sym004, a Novel Anti-EGFR Antibody Mixture, Augments Radiation Response in Human Lung and Head and Neck Cancers. MOLECULAR CANCER THERAPEUTICS 12:2772-2781(2013).
- Maiga, B; Dolo, A; et al. Human Candidate Polymorphisms in Sympatric Ethnic Groups Differing in Malaria Susceptibility in Mali. PLOS ONE 8:-(2013).
