Prkar2b
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Official Full Name
protein kinase, cAMP-dependent, regulatory, type II, beta -
Overview
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol. -
Synonyms
PRKAR2B;protein kinase, cAMP-dependent, regulatory, type II, beta;PRKAR2;cAMP-dependent protein kinase type II-beta regulatory subunit;H_RG363E19.2;WUGSC:H_RG363E19.2;cAMP-dependent protein kinase type II-beta regulatory chain;RII-BETA
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- His
- Myc&DDK
- Non
- GST
- His&Fc&Avi
Involved Pathway
Prkar2b involved in several pathways and played different roles in them. We selected most pathways Prkar2b participated on our site, such as Apoptosis,Insulin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Prkar2b were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Apoptosis | PIK3CD,CAPN2L,PANK1A,Casp3,AKT3A,ATM,BID,TNFRSF10D,IRF4,TNFRSF10A |
| Insulin signaling pathway | HKDC1,PPP1CB,CALM2B,GSK3AA,CBLB,INS2,SHC3,FLOT2,RAPGEF1B,FLOT1A |
Protein Function
Prkar2b has several biochemical functions, for example, cAMP binding,cAMP-dependent protein kinase inhibitor activity,cAMP-dependent protein kinase regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Prkar2b itself. We selected most functions Prkar2b had, and list some proteins which have the same functions with Prkar2b. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein domain specific binding | POU2F2,SKI,DBNL,CA,PTPN11,RAN,FOXA1,YWHAG,TBL1X,MECP2 |
| cAMP-dependent protein kinase inhibitor activity | PKIG,PKIA,PKIB,PRKAR1B,PRKAR1A,PRKAR2A,PRKAG2 |
| protein kinase A catalytic subunit binding | GSK3B,PKIA,SOX9,PRKAR2A,PJA2,PRKAR1B,KCNQ1,RYR2,GSK3A,CSK |
| ubiquitin protein ligase binding | RNF31,XRCC5,CUL5A,TPI1,SPG20,BRCA1,DNAJA1,SLC22A18,TRIOBP,CD40 |
| cAMP-dependent protein kinase regulator activity | PRKAR1AB,PRKAG1,PRKAR1A,PRKAR1B,PRKAR2AA,PRKAR1AA,PRKAR2A,PRKAG2,PRKAR2AB,CXCL10 |
| cAMP binding | CNGA2,PDE2A,BVES,HCN4,POPDC2,PDE10A,PDE4D,RAPGEF4,PRKAR1A,PRKAR2A |
Interacting Protein
Prkar2b has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Prkar2b here. Most of them are supplied by our site. Hope this information will be useful for your research of Prkar2b.
PRKACA;3',5'-cyclic amp;PRKACB;ARFGEF2;7-ch-c_amp;sp-8-br-7-ch-camps;7-ch-cgmp;kemptide;p03259-2;2_aha_camp;8-aha-camp;8-aha-omethyladenosine;PCM1
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