Pggt1b
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Official Full Name
protein geranylgeranyltransferase type I, beta subunit -
Overview
Protein geranylgeranyltransferase type I (GGTase-I) transfers a geranylgeranyl group to the cysteine residue of;candidate proteins containing a C-terminal CAAX motif in which A is an aliphatic amino acid and X is leucine;(summarized by Zhang et al., 1994 (PubMed 8106351)). The enzyme is composed of a 48-kD alpha subunit (FNTA; MIM;134635) and a 43-kD beta subunit, encoded by the PGGT1B gene. The FNTA gene encodes the alpha subunit for both;GGTase-I and the related enzyme farnesyltransferase. -
Synonyms
PGGT1B;protein geranylgeranyltransferase type I, beta subunit;geranylgeranyl transferase type-1 subunit beta;BGGI;GGTI;GGTase-I-beta;geranylgeranyltransferase type I beta subunit;geranylgeranyl transferase type I subunit beta;type I protein gerany
Recombinant Proteins
- Rat
- Mouse
- Zebrafish
- Rhesus macaque
- Human
- E.coli
- Mammalian Cell
- HEK293
- Non
- GST
- His
- His&Fc&Avi
Involved Pathway
Pggt1b involved in several pathways and played different roles in them. We selected most pathways Pggt1b participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with Pggt1b were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
Pggt1b has several biochemical functions, for example, contributes_to CAAX-protein geranylgeranyltransferase activity,CAAX-protein geranylgeranyltransferase activity,catalytic activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Pggt1b itself. We selected most functions Pggt1b had, and list some proteins which have the same functions with Pggt1b. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | GDPD1,RNF17,ITGB2,ZNF12,ALPPL2,ZFP30,PPM1F,ATP1A3,MAN1A,FAHD1 |
| zinc ion binding | MID2,GFI1AB,FBXL19,TRIM40,CPO,YAF2,Adamts19,VDRA,PDLIM5B,AMZ2 |
| catalytic activity | ALDOAB,AZIN1B,GAD1B,ISOC1,SYN2A,SYN2,CKMT2A,GOT2B,YDJC,DBH |
| transferase activity | Mettl11b,BMPR1BB,PIP5K1AA,B3GNT2A,HS6ST1A,PKMA,RPS6KA3B,SRPK1B,POC1BL,NAT15 |
| prenyltransferase activity | COQ2,UBIAD1,PTAR1 |
| contributes_to CAAX-protein geranylgeranyltransferase activity | FNTA |
| protein geranylgeranyltransferase activity | UBIAD1,FNTA |
| contributes_to drug binding | ATP1A2,ATP1B1 |
Interacting Protein
Pggt1b has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Pggt1b here. Most of them are supplied by our site. Hope this information will be useful for your research of Pggt1b.
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