Parp2

  • Official Full Name

    poly (ADP-ribose) polymerase 2

  • Overview

    This gene encodes poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. The basic residues within the N-terminal region of this protein may bear potential DNA-binding properties, and may be involved in the nuclear and/or nucleolar targeting of the protein. Two alternatively spliced transcript variants encoding distinct isoforms have been found.

  • Synonyms

    PARP2;poly (ADP-ribose) polymerase 2;ADP ribosyltransferase (NAD+;poly(ADP ribose) polymerase) like 2 , ADPRTL2, poly (ADP ribose) polymerase family, member 2;poly [ADP-ribose] polymerase 2;ADP ribosyltransferase like 2;ADPRT 2;ADPRT-2;ADPRT2;ADPRTL 2;ADPRTL 3;ADPRTL2;ADPRTL3;hPARP 2;hPARP-2;hPARP2;NAD(+) ADP ribosyltransferase 2;NAD(+) ADP-ribosyltransferase 2;pADPRT 2;pADPRT-2;pADPRT2;PARP 2;PARP-2;PARP2_HUMAN;Poly (ADP ribose) polymerase family member 2;Poly (ADP ribosyl) transferase like 2;Poly [ADP ribose] synthetase 2;Poly(ADP ribose) synthetase;Poly[ADP-ribose] synthase 2;OTTHUMP00000231900;OTTHUMP00000231902;OTTHUMP00000231904;poly(ADP-ribose) synthetase;poly[ADP-ribose] synthetase 2;poly (ADP-ribosyl) transferase-like 2;poly (ADP-ribose) polymerase family, member 2;ADP-ribosyltransferase (NAD+;poly(ADP-ribose) polymerase)-like 2

Recombinant Proteins

  • Mouse
  • Human
  • Rhesus macaque
  • Zebrafish
  • Sf21 Cells
  • Mammalian Cells
  • Insect Cells
  • Sf9 Cells
  • E.coli
  • HEK293
  • Insect cells
  • His
  • GST
  • Non
  • His&Fc&Avi
  • GST&His
Cat.# Product name Source (Host) Species Tag Protein Length Price
Parp2-453M Active Recombinant Mouse Parp2, His-tagged Sf21 Cells Mouse His
PARP2-12373M Recombinant Mouse PARP2 Protein Mammalian Cells Mouse His
PARP2-157H Recombinant Human PARP2 Protein, GST-tagged Insect Cells Human GST 2-583
PARP2-3308R Recombinant Rhesus monkey PARP2 Protein, His-tagged Mammalian Cells Rhesus macaque His
PARP2-433H Recombinant Human Poly (ADP-ribose) Polymerase 2, GST-tagged Sf9 Cells Human GST 2-583 a.a.
Parp2-613M Recombinant Mouse Poly (ADP-ribose) Polymerase Family, Member 2 Sf9 Cells Mouse Non Full L.
Parp2-641M Recombinant Mouse Parp2, His-tagged Sf21 Cells Mouse His
PARP2-7559H Recombinant Human PARP2, His-tagged E.coli Human His 233-583aa
PARP2-8014Z Recombinant Zebrafish PARP2 Mammalian Cells Zebrafish His
Kit-1799 PARP2 Chemiluminescent Assay Kit Non
Kit-1800 PARP2 Colorimetric Assay Kit Non
Kit-1801 PARP2 Homogeneous Assay Kit Non
PARP2-006H Recombinant Human PARP2 Protein, GST-tagged Insect Cells Human GST 2-583
PARP2-3126R Recombinant Rhesus Macaque PARP2 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
PARP2-3126R-B Recombinant Rhesus Macaque PARP2 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
PARP2-3858H Recombinant Human PARP2 Protein (Ser223-Trp583), N-His tagged E.coli Human His Ser223-Trp583
PARP2-4533H Recombinant Human PARP2 protein, His-tagged E.coli Human His 233-583aa
PARP2-6506M Recombinant Mouse PARP2 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
PARP2-6506M-B Recombinant Mouse PARP2 Protein Pre-coupled Magnetic Beads HEK293 Mouse
PARP2-6754H Recombinant Human PARP2 protein, GST&His-tagged Insect cells Human GST&His 1-583aa

    Involved Pathway

    Parp2 involved in several pathways and played different roles in them. We selected most pathways Parp2 participated on our site, such as Base Excision Repair,DNA Damage Recognition in GG-NER,DNA Double-Strand Break Repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with Parp2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    DNA Repair ASCC2,BABAM1,YY1,ZBTB32,PPP4CA,KDM4A,INO80C,CHD1L,PPP4R2B,CHEK1
    DNA Damage Recognition in GG-NER INO80B,COPS4,COPS5,YY1,DDB2,COPS7A,COPS6,ACTL6A,GPS1,COPS8
    Base excision repair UNG,xthA,POLL,HMGB1A,POLD3,POLE2,TDG,POLD4,NEIL2,TDG.1
    Formation of Incision Complex in GG-NER USP45,CETN2,PIAS3,CHD1L,RNF111,DDB1,DDB2
    DNA Double-Strand Break Repair GEN1,RAD17,PPP4R2,BARD1,FUZ,RBBP8,POLD3,BAZ1B,FAM175A,DNA2
    Global Genome Nucleotide Excision Repair (GG-NER) INO80E,ACTL6A,YY1A,ACTR5,GPS1,TFPT,INO80C,INO80,COPS6,COPS7A
    Dual Incision in GG-NER DDB2,DDB1,CHD1L

    Protein Function

    Parp2 has several biochemical functions, for example, DNA binding,NAD+ ADP-ribosyltransferase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Parp2 itself. We selected most functions Parp2 had, and list some proteins which have the same functions with Parp2. You can find most of the proteins on our site.

    Function Related Protein
    protein binding CCDC87,IL5,PRTFDC1,WDR20,TSHR,SNAPC5,GRIK5,FRA10AC1,ZNF3,PSMC6
    DNA binding HIST1H2AG,ZNF224,ZFP131,HER8.2,NKX1.2LB,EGR3,JUNBA,ZNF771,ZNF157,ZFP92
    NAD+ ADP-ribosyltransferase activity GIG2E,PARP16,PARP15,PARP1,PARP9,GIG2J,TIPARP,PARP11,GIG2Q,TNKS2

    Interacting Protein

    Parp2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Parp2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Parp2.

    FKBP3;STAC;FAM168B;VPS37C;nad+;mgc:39545;NDUFA4;SYNJ2;DFFB;MYO1D;RTN3;IFNA16;PCCA;HMGN2;HIST1H1E;CD58;PTMS

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