PYGM
-
Official Full Name
phosphorylase, glycogen, muscle -
Overview
This gene encodes a muscle enzyme involved in glycogenolysis. Highly similar enzymes encoded by different genes are found in liver and brain. Mutations in this gene are associated with McArdle disease (myophosphorylase deficiency), a glycogen storage disease of muscle. Alternative splicing results in multiple transcript variants. -
Synonyms
PYGM;phosphorylase, glycogen, muscle;phosphorylase, glycogen;muscle;glycogen phosphorylase, muscle form;glycogen storage disease type V;McArdle syndrome;myophosphorylase
Recombinant Proteins
- Mouse
- Rhesus macaque
- Cynomolgus
- Human
- Mammalian Cell
- E.coli
- HEK293
- Mammalian cells
- HEK293T
- His
- Non
- Flag
- His&Fc&Avi
- Myc&DDK
Involved Pathway
PYGM involved in several pathways and played different roles in them. We selected most pathways PYGM participated on our site, such as Starch and sucrose metabolism,Metabolic pathways,Insulin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PYGM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Insulin resistance | PRKAG2A,GYS1,IKBKB,AKT2,PPP1CAB,MAPK8B,SLC2A1,SLC2A4,SLC27A2,PTPRF |
| Insulin signaling pathway | EIF4E2,PRKAG1,TRIP10,EXOC7,RAF1,FOXO1,SHC4,MAP2K2B,PRKAR2A,MAPK8A |
| Metabolic pathways | DAO1,PRPS1A,IDO2,CYP27B1,UGP2,MCCC2,UCKL1,LIPC,CTPS1A,ENOPH1 |
| Starch and sucrose metabolism | UGT1A3,PYGMA,UGT1A6,GBA3,UGP2A,HKDC1,UGDH,G6PCA.1,UGT2B15,AMY1B |
Protein Function
PYGM has several biochemical functions, for example, AMP binding,carbohydrate binding,drug binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PYGM itself. We selected most functions PYGM had, and list some proteins which have the same functions with PYGM. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| pyridoxal phosphate binding | PDXK,TAT,PYGMA,GOT2B,GPT2,HINT2,SDS,SPTLC2A,SRR,CSAD |
| protein binding | SNX32,AMY1A,ORAI3,RNF11,SEC22C,FNBP1,RADIL,NUP153,TMEM79,EFNA3 |
| drug binding | SETD6,DAAM2,GPR30,P2RX1,HTR2A,CHRM1,GABRA1,CHRNA3,CYP2C9,NAMPT |
| AMP binding | PRKAG2,PRKAG1,CYB5R3,PYGL,ACSS2,ACSS1,APRT,FBP1,PRPS2,PRPS1 |
| carbohydrate binding | ZG16B,CLEC7A,PRPS2,GALNTL4,CLEC12A,PRG3,CD302,LGALS1L1,DGCR2,LY75 |
| glycogen phosphorylase activity | PYGMB,PYGMA,PYGL,PYGB |
Interacting Protein
PYGM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PYGM here. Most of them are supplied by our site. Hope this information will be useful for your research of PYGM.
PRKAB2;WDYHV1;6319953;DEGS1;Ccdc15;MAP3K3;INPP5K;PACSIN3;CLASP2;GBAS;SRP72;LMNA;TRAPPC2;DNM2;IGBP1;SGCG
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