PTTG1

  • Official Full Name

    pituitary tumor-transforming 1

  • Overview

    The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus.

  • Synonyms

    PTTG1;pituitary tumor-transforming 1;TUTR1;securin;EAP1;ESP1 associated protein 1;HPTTG;PTTG;tumor transforming protein 1;AW555095;C87862;Cut2;EAP 1;Esp1-associated protein;MGC126883;MGC138276;Pds1;Pituitary tumor transforming 1;Pituitary tumor transforming protein 1;Pituitary tumor-transforming 1, isoform CRA_a;Pituitary tumor-transforming 1, isoform CRA_b;Pituitary tumor-transforming gene 1;Pituitary tumor-transforming gene 1 protein;PTTG 1;PTTG1 protein;PTTG1_HUMAN;Pttg3;TUMOR TRANSFORMING 1;TUMOR-TRANSFORMING 1;Tumor-transforming protein 1;TUTR 1;OTTHUMP00000160845;OTTHUMP00000224265;OTTHUMP00000224267;ESP1-associated protein 1

Recombinant Proteins

  • Human
  • Rhesus macaque
  • Chicken
  • Mouse
  • Zebrafish
  • E.coli
  • Mammalian Cell
  • Human
  • HEK293
  • Mammalian cells
  • HEK293T
  • His
  • Non
  • His&T7
  • Myc&DDK
  • His&Fc&Avi
  • Flag
Cat.# Product name Source (Host) Species Tag Protein Length Price
PTTG1-29693TH Recombinant Human PTTG1, His-tagged E.coli Human His Full L. 1-202 a.a.
PTTG1-3713R Recombinant Rhesus monkey PTTG1 Protein, His-tagged Mammalian Cell Rhesus macaque His
PTTG1-4522H Recombinant Human Pituitary Tumor-Transforming 1, His-tagged Human Human His 1-202 a.a.
PTTG1-487H Recombinant Human Pituitary Tumor-transforming 1 E.coli Human Non
PTTG1-5108C Recombinant Chicken PTTG1 Mammalian Cell Chicken His
Pttg1-8040M Recombinant Mouse Pttg1 protein, His & T7-tagged E.coli Mouse His&T7 Ala2~Ile199
PTTG1-8265Z Recombinant Zebrafish PTTG1 Mammalian Cell Zebrafish His
PTTG1-2667HCL Recombinant Human PTTG1 293 Cell Lysate HEK293 Human Non
PTTG1-120H Recombinant Human PTTG1 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 Human Myc&DDK
PTTG1-1806H Recombinant Human PTTG1 Protein, His (Fc)-Avi-tagged HEK293 Human His&Fc&Avi
PTTG1-1806H-B Recombinant Human PTTG1 Protein Pre-coupled Magnetic Beads HEK293 Human
PTTG1-1819HFL Recombinant Full Length Human PTTG1 Protein, C-Flag-tagged Mammalian cells Human Flag Full L.
PTTG1-3530R Recombinant Rhesus Macaque PTTG1 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
PTTG1-3530R-B Recombinant Rhesus Macaque PTTG1 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
Pttg1-5254M Recombinant Mouse Pttg1 Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
PTTG1-6693H Recombinant Human PTTG1 Protein (Ala2-Ile202), N-His tagged E.coli Human His Ala2-Ile202

    Involved Pathway

    PTTG1 involved in several pathways and played different roles in them. We selected most pathways PTTG1 participated on our site, such as Cell cycle,Oocyte meiosis,HTLV-I infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTTG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Oocyte meiosis YWHABA,INS2,CALM1,CCNB1,PLCZ1,CUL1,YWHAG,MOS,YWHAG1,YWHAQB
    Cell cycle ARPP19A,CDK4,DPF1,NUPL2,BARD1,ORC1,SYCE1,DMC1,CDK11B,CDKN2B
    HTLV-I infection FDPS,CCNB2,MAP3K1,CREM,PTTG2,HLA-DQB1,PRKACA,NFKB1,PDGFRB,ATF3

    Protein Function

    PTTG1 has several biochemical functions, for example, SH3 domain binding,cysteine-type endopeptidase inhibitor activity,peptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PTTG1 itself. We selected most functions PTTG1 had, and list some proteins which have the same functions with PTTG1. You can find most of the proteins on our site.

    Function Related Protein
    protein binding CDC42,RPUSD4,PELP1,PIM2,RTN3,USP19,DBF4B,CASQ2,ZFP64,CDK17
    transcription factor activity, sequence-specific DNA binding GATA1,FOXP1B,GLIS2,SLC12A9,KDM3A,BCL3,KLF11,ZFY2,SIX3,Ar
    peptidase inhibitor activity UMODL1,SERPINA1A,KAL1A,SERPINB1C,NGP,SERPINA3C,EPPIN,SPINK3,SERPINA3M,SERPINB11
    SH3 domain binding PLSCR1,SH3BP5LA,CYBA,USP8,SHANK1,ADAM17,CNTNAP1,KHDRBS1,PTTG2,SH3BP5L
    cysteine-type endopeptidase inhibitor activity CSTL1,CST5,BIRC5,SERPINB4,CST8,BIRC5A,SERPINB13,FETUB,WFDC2,CARD16

    Interacting Protein

    PTTG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTTG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTTG1.

    ESPL1;Espl1;PLCG2;DECR1;CRK;SYNCRIP;YEATS4;BAG6;PMS1;HSPG2

    Resources

    References

    • Ishitsuka, Y; Kawachi, Y; et al. Pituitary tumor-transforming gene 1 as a proliferation marker lacking prognostic value in cutaneous squamous cell carcinoma. EXPERIMENTAL DERMATOLOGY 22:318-322(2013).
    • Hsueh, C; Lin, JD; et al. Prognostic significance of pituitary tumour-transforming gene-binding factor (PBF) expression in papillary thyroid carcinoma. CLINICAL ENDOCRINOLOGY 78:303-309(2013).

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