PTS
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Official Full Name
6-pyruvoyltetrahydropterin synthase -
Overview
The enzyme encoded by this gene catalyzes the elimination of inorganic triphosphate from dihydroneopterin triphosphate, which is the second and irreversible step in the biosynthesis of tetrahydrobiopterin from GTP. Tetrahydrobiopterin, also known as BH(4), is an essential cofactor and regulator of various enzyme activities, including enzymes involved in serotonin biosynthesis and NO synthase activity. Mutations in this gene result in hyperphenylalaninemia. -
Synonyms
PTS;6-pyruvoyltetrahydropterin synthase;6-pyruvoyl tetrahydrobiopterin synthase;PTPS;6 pyruvoyl tetrahydrobiopterin synthase;6 pyruvoyl tetrahydropterin synthase;6 pyruvoyltetrahydropterin synthase;EC 4.2.3.12;FLJ97081;OTTHUMP00000235385;PTP synthase;PTPS_HUMAN
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- Zebrafish
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
PTS involved in several pathways and played different roles in them. We selected most pathways PTS participated on our site, such as Folate biosynthesis,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | NDUFC1,ATP6V0CB,CELL,EPHX2,Acsm2a,UGT1A3,RDH8A,NDUFB2,CYCSB,DTYMK |
| Folate biosynthesis | QDPRB2,GCH1,SPR,SPRA,GCH2,ALPPL2,ALPL,GGH,DHFRL1,MOCS2 |
Protein Function
PTS has several biochemical functions, for example, 6-pyruvoyltetrahydropterin synthase activity,identical protein binding,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTS itself. We selected most functions PTS had, and list some proteins which have the same functions with PTS. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | RPE,MOB1A,CYP2J5,ZNF684,ZDHHC24,ZFP746,REV3L,KCND2,RUNX1T1,ATP1A4 |
| protein binding | HOXA9,WDR4,USP22,KRTAP5-9,RASSF7,HAUS1,CPNE3,RGS19,RGS14,SP1 |
| protein homodimerization activity | CADM1B,CTBP1,CHRNA7,HMGCL,SNF8,XPNPEP1,PDCD6,OLIG2,PVRL1A,KLHL7 |
| identical protein binding | RUVBL2,BAG2,BIRC5,KHDC1A,PTK6,MUL1,KCNJ10,RYR2,YWHAZ,PRKD1 |
Interacting Protein
PTS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTS here. Most of them are supplied by our site. Hope this information will be useful for your research of PTS.
SDCBP;COIL;LNX1;THAP10;FXR2
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References
- Goekbuget, N; Kantarjian, H; et al. An Evaluation of Molecular Response in a Phase 2 Open-Label, Multicenter Confirmatory Study in Patients (pts) with Relapsed/Refractory B-Precursor Acute Lymphoblastic Leukemia (r/r ALL) Receiving Treatment with the BiTE (R) Antibody Construct Blinatumomab. BLOOD 124:-(2014).
- Jabbour, E; O'Brien, S; et al. Prognostic Factors for Outcome in Patients (pts) with Refractory and Relapsed Acute Lymphocytic Leukemia (ALL) Treated with Inotuzumab Ozogamicin (IO), a CD22 Monoclonal Antibody. BLOOD 124:-(2014).
