PTPRN
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Official Full Name
protein tyrosine phosphatase, receptor type, N -
Overview
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants. -
Synonyms
PTPRN;protein tyrosine phosphatase, receptor type, N;receptor-type tyrosine-protein phosphatase-like N;Receptor type tyrosine protein phosphatase like N;CA 512;FLJ16131;IA 2;IA 2/PTP;IA2;IA2/PTP;ICA 3;ICA 512;ICA3;ICA512;IA-2
Recombinant Proteins
- Human
- Rat
- E.coli
- Insect Cells
- Mammalian Cell
- Insect cell
- Insect Cell
- HEK293 cells
- HEK293
- Yeast
- Mammalian cells
- Non
- His
- GST
- Flag
- MAT
- His&Fc&Avi
- His&Myc
Involved Pathway
PTPRN involved in several pathways and played different roles in them. We selected most pathways PTPRN participated on our site, such as Type I diabetes mellitus, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTPRN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Type I diabetes mellitus | HLA-DMA,H2-Q10,IFNG,HSPD1,HLA-DRB3,H2-AA,CD86,IL12B,GAD1,GAD2 |
Protein Function
PTPRN has several biochemical functions, for example, GTPase binding,protein binding,NOT protein tyrosine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PTPRN itself. We selected most functions PTPRN had, and list some proteins which have the same functions with PTPRN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| spectrin binding | CAMSAP1L1,MYO7A,GNB1,DYNC1I1,PDE6G,ADD1,STX4A,DCTN2,USH1G,EPB41 |
| GTPase binding | AIMP1,GNB1,LCP1,SH3GL1,RASA1,MARCH5,IARS,GM5506,VPS41,ENO1 |
| protein binding | CMKLR1,PTH2R,PIN1,BIK,FBXW11,CIZ1,VPS36,ZNF460,CHUK,CREB3 |
Interacting Protein
PTPRN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTPRN here. Most of them are supplied by our site. Hope this information will be useful for your research of PTPRN.
PTPRT;PPIA;PTPRS;MADD;SNX19;SPTBN4
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References
