PTPN22
-
Official Full Name
protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
Recombinant Proteins
- Mouse
- Rhesus macaque
- Zebrafish
- Human
- Rat
- Mammalian Cell
- E.coli
- HEK293
- Wheat Germ
- His
- His&T7
- Non
- GST
- His&Fc&Avi
Involved Pathway
PTPN22 involved in several pathways and played different roles in them. We selected most pathways PTPN22 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PTPN22 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
PTPN22 has several biochemical functions, for example, SH3 domain binding,kinase binding,phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PTPN22 itself. We selected most functions PTPN22 had, and list some proteins which have the same functions with PTPN22. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | MARCKSL1,GET4,TMEM27,RBM4,KRTAP19-5,SP4,RNF165,TMF1,ARMC9,C1orf187 |
| ubiquitin protein ligase binding | CUL4B,MFN2,PIAS1,CUL5,PIAS4,TRIB1,UBE2C,NFKBIA,ACTG1,CASC3 |
| phosphatase activity | ATP1A1,PTPRJ,PTPRJA,PTPN4A,PTPN2B,PTPN4B,MINPP1A,PTPRO,CTDNEP1B,DUSP27 |
| kinase binding | NTRK1,SNAI1,C2orf44,PFKL,BCL10,STUB1,CHP,RPS3,TAX1BP1,WWC1 |
| SH3 domain binding | NOXA1,PARK2,ERRFI1,ABL1,REPS1,INPPL1,ELMO2,EFS,ADAM15,SHANK2 |
| protein tyrosine phosphatase activity | SSH3,PTP4A2B,PALD1,PTPRK,PTENB,PTPN4B,DUSP28,DUSP12,DUSP19B,PTPN11 |
Interacting Protein
PTPN22 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTPN22 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTPN22.
LCK;CD247;SKAP2;ZAP70;PSTPIP1
Resources
Related Services
Related Products
References
- Marino, M; Latrofa, F; et al. Role of genetic and non-genetic factors in the etiology of Graves' disease. JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION 38:283-294(2015).
- Cao, YL; Liu, K; et al. PTPN22 R620W Polymorphism and ANCA Disease Risk in White Populations: A Metaanalysis. JOURNAL OF RHEUMATOLOGY 42:292-299(2015).
