PTPMT1

  • Official Full Name

    protein tyrosine phosphatase, mitochondrial 1

  • Overview

    Protein phosphatase that specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues. Probably involved in regulation of insulin secretion in pancreatic beta cells.

  • Synonyms

    PTPMT1;protein tyrosine phosphatase, mitochondrial 1;protein-tyrosine phosphatase mitochondrial 1;DUSP23;MOSP;PLIP;PTEN-like phosphatase;phosphoinositide lipid phosphatase;NB4 apoptosis/differentiation related protein;PNAS-129;FLJ46081

Recombinant Proteins

  • Human
  • Rhesus macaque
  • Zebrafish
  • Chicken
  • E.coli
  • Mammalian Cell
  • HEK293
  • His
  • Non
  • His&Fc&Avi
  • His&SUMO
Cat.# Product name Source (Host) Species Tag Protein Length Price
PTPMT1-2547H Active Recombinant Human PTPMT1 protein(Lys28-Thr201), His-tagged E.coli Human His Lys28-Thr201
PTPMT1-31117TH Recombinant Human PTPMT1, His-tagged E.coli Human His 174 amino acids
PTPMT1-3703R Recombinant Rhesus monkey PTPMT1 Protein, His-tagged Mammalian Cell Rhesus macaque His
PTPMT1-5044Z Recombinant Zebrafish PTPMT1 Mammalian Cell Zebrafish His
PTPMT1-5223C Recombinant Chicken PTPMT1 Mammalian Cell Chicken His
PTPMT1-1436HCL Recombinant Human PTPMT1 cell lysate Human Non
PTPMT1-3520R Recombinant Rhesus Macaque PTPMT1 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
PTPMT1-3520R-B Recombinant Rhesus Macaque PTPMT1 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
PTPMT1-4636H Recombinant Human PTPMT1 protein, His-SUMO-tagged E.coli Human His&SUMO 28-201aa

    Involved Pathway

    PTPMT1 involved in several pathways and played different roles in them. We selected most pathways PTPMT1 participated on our site, such as 3-phosphoinositide degradation,Glycerophospholipid biosynthesis,Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTPMT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Metabolism CA5B,CYP24A1,CPNE1,PDK3B,ATP5S,FA2H,PPM1LA,Alb,HSD17B11,ACY3.1
    3-phosphoinositide degradation INPP5F
    Glycerophospholipid biosynthesis PLD6,AGPAT1,PLD4,BCHE,CHAT,AGPAT2,CPNE1,ABHD4,PLB1,PNPLA8
    Phospholipid metabolism PLD6,AWAT1,CPNE7,SLC44A5B,PEMT,ABHD3,CPNE1,SACM1LB,FIG4,ARF3
    Synthesis of PG PLD6
    Metabolism of lipids and lipoproteins INSIG1,ACOT11A,CYP2N13,ALOX5AP,ARSD,CERS3B,MED9,CYP27A1,CDK19,SGMS2

    Protein Function

    PTPMT1 has several biochemical functions, for example, phosphatidylglycerophosphatase activity,phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTPMT1 itself. We selected most functions PTPMT1 had, and list some proteins which have the same functions with PTPMT1. You can find most of the proteins on our site.

    Function Related Protein
    protein tyrosine/serine/threonine phosphatase activity SSH1,PTENB,EPM2A,CTDSPL2A,MTMR2,PTP4A2B,DUSP16,SSH3,DUSP11,DUSP19B
    protein tyrosine phosphatase activity MTMR1,PTENB,MTMR4,DUSP13,DUSP7,PALD1A,PTPRR,LRP8,DUPD1,DUSP9
    phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity EPM2A,INPP5B,OCRL,SYNJ2,INPP5E
    protein binding SPTSSB,FUBP1,C1orf21,PAM16,SGOL1,G3BP1,TK1,RPS19,CIC,HYI

    Interacting Protein

    PTPMT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTPMT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTPMT1.

    MDFI;RGS20;KRTAP2-3;TRIM27;KRTAP5-9;KRTAP10-7

    Resources

    References

    • Park, JS; Lee, SJ; et al. Gastric Autoantigenic Proteins in Helicobacter Pylori Infection. YONSEI MEDICAL JOURNAL 54:1342-1352(2013).
    • Matsumoto, C; Ito, M; et al. Genes that characterize T-3-predominant Graves' thyroid tissues. EUROPEAN JOURNAL OF ENDOCRINOLOGY 168:137-144(2013).

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