PTK2
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Official Full Name
protein tyrosine kinase 2 -
Overview
Focal adhesion kinase subfamily consists of the non-receptor proline-rich protein tyrosine kinases (PTKs). Two members of the family are focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2). These two kinases have molecular mass between 110-125 kDa and are closely related in their structure. The presence<br/>of two proline-rich motifs within the C-terminal domains is conserved. FAK is a nonreceptor and nonmembrane associated PTK which does not contain Src homology 2 (SH2) or SH3 protein interaction domains. The centrally located kinase domain of FAK is flanked by large N- and C-terminal noncatalytic domains. FAK links integrin receptors to intracellular signaling pathways that are important for cell growth, survival, and migration. Integrin receptor engagement with ligands such as fibronectin can stimulate FAK autophosphorylation which enables FAK to function within a network of integrin-stimulated signaling pathways leading to the activation of targets such as the ERK and JNK/mitogen-activated protein kinase pathways. Recent study reveals that FAK is essential for angiogenesis in the embryo, functions in heart development and modulates the response of cardiomyocytes to pressure overload in adult mice. -
Synonyms
PTK2;protein tyrosine kinase 2;FAK;FADK;FAK1;FADK 1;FRNK;PPP1R71;pp125FAK;Protein-tyrosine kinase 2;focal adhesion kinase 1;FADK 1;FAK-related non-kinase polypeptide;protein phosphatase 1, regulatory subunit 71;P_001186578.1;EC 2.7.10.2;EC 2.7.10;NP_005598.3;EC 2.7.10.2;NP_722560.1;OTTHUMP00000226325;OTTHUMP00000226326;OTTHUMP00000226334;OTTHUMP00000226350;OTTHUMP00000226586;OTTHUMP00000226318;OTTHUMP00000226320
Recombinant Proteins
- Human
- Mouse
- Rat
- Chicken
- Marsupials
- Sf9 Cells
- HEK293
- Mammalian Cells
- Insect Cells
- E.coli
- His
- DDK
- Myc
- Non
- GST
- Flag
- T7
- Avi
- Fc
Involved Pathway
PTK2 involved in several pathways and played different roles in them. We selected most pathways PTK2 participated on our site, such as ErbB signaling pathway,Chemokine signaling pathway,PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Leukocyte transendothelial migration | CLDN15,ESAM,ICAM1,RAP1A,ARHGAP5,ACTN3,PIK3CA,MAPK12,CLDN5,CLDN4 |
| Proteoglycans in cancer | PLAUR,HSPG2,FZD5,DROSHA,RDX,WNT7A,FLNA,PIK3CD,IGF2,HRAS |
| Axon guidance | ROBO1,KCNQ2,ST8SIA2,SLIT3,EPHA4A,SEMA3B,ARHGEF28,NRP1A,EPHA6,SEMA6A |
| Chemokine signaling pathway | CXCR1,NCF1,GNG7,CCL22,NRAS,PAK1,WASL,CXCL2,PXN,AMCF-II |
| ErbB signaling pathway | PIK3CG,GRB2A,MAPK8B,BADB,CAMK2D,STAT5A,GRB2,NRAS,PAK7,ERBB4 |
| Regulation of Actin Cytoskeleton | PIP4K2C,ITGB6,FGF6B,CD14,PPP1R12C,PIK3CA,ROCK1,BDKRB1,TMSB,MOS |
| Small cell lung cancer | BIRC7,IKBKG,PIK3R1,SKP2,CCND1,TRAF4,ITGA3,RARB,LAMC1,PIK3CA |
| VEGF signaling pathway | PIK3CD,RAC2,CDC42L,VEGFAB,HSPB1,MAP2K1,MAPKAPK3,PPP3CCB,AKT2L,PLA2G4C |
| Pathways in cancer | SMAD4,AXIN1,DAPK3,NCOA4,VEGFC,AHA-1,FGF3,SKP2,WNT2B,CSF1R |
Protein Function
PTK2 has several biochemical functions, for example, ATP binding,JUN kinase binding,SH2 domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTK2 itself. We selected most functions PTK2 had, and list some proteins which have the same functions with PTK2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein tyrosine kinase activity | FGFR1A,EPHA4B,JAK2,DYRK3,MAP2K2,BTK,LCK,JAK2A,JAK1,Fert2 |
| actin binding | ITGB1,VASPA,MTSS1L,DIAP3,FHOD3,PFN3,PPP1R9B,MKL1,PARVB,GIPC1 |
| JUN kinase binding | MAPK8IP3,MAD2L2,SPAG9A,SPAG9,GSTP1 |
| non-membrane spanning protein tyrosine kinase activity | HCK,PTK6B,TNK2,RIPK2,SRMS,WEE1,FES,ZAP70,PTK2BB,JAK3 |
| protein kinase activity | STK25A,ACVR2AA,NEK10,CSNK1D,STK25,PRKACAB,CCL8,LTK,PRPF4BB,GSK3AA |
| protein binding | HBQ1,DDX21,FOXH1,RAB24,PPP1R12B,MRPL20,EDC3,FBXW11,USP6,IFT20 |
| protein kinase binding | PTPN1,IFNAR2,GSK3B,RCC2,SPRY2,SHC1,CSPG4,YWHAZ,DPYSL2,SKI |
| ATP binding | SMG1,MOV10B.1,STRADB,JAK2,UBE2M,PMS2,ATP1A1A.1,VCP,STK25B,ACTC1 |
| receptor binding | PAOX,HCST,WNT2BB,SNX17,TRDN,NRG4,SELPLG,PCSK1N,PANX1,FGF12A |
Interacting Protein
PTK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTK2.
SRC;PXN
Resources
Research Area
Cancer Drug TargetsKinases and Phosphatases in Endothelial Cells
Repulsive Guidance Molecules and Receptors
Intracellular Kinases in the Akt Pathway
Adherens Junction Proteins in Endothelial Cells
Focal Adhesion Proteins in Endothelial Cells
Adherens Junction Proteins in VSMC
Focal Adhesion Proteins in VSMC
Intracellular Signaling Molecules in Angiogenesis
Mesenchymal Cells and EMT
Focal Adhesion Kinase (FAK)
Kinases Localized to Focal Adhesions
FAK-Src Signaling
Related Services
Related Products
References
- Devadas, D; Koithan, T; et al. Herpes Simplex Virus Internalization into Epithelial Cells Requires Na+/H+ Exchangers and p21-Activated Kinases but neither Clathrin-nor Caveolin-Mediated Endocytosis. JOURNAL OF VIROLOGY 88:13378-13395(2014).
- Weisser, M; Yeh, RF; et al. PTK2 expression and immunochemotherapy outcome in chronic lymphocytic leukemia. BLOOD 124:420-425(2014).
